hIVIG and effector-silent mAb 26.4 ameliorate bleeding in the APLDQ murine model of FNAIT
| Pre-immunized BALB/c female bred with APLDQ male . | Treatment . | Total pups born from 4 females . | No. of dead or bleeding pups . | % Affected . |
|---|---|---|---|---|
| 1st litter | No treatment | 16 | 5 | 31 |
| 2nd litter | Treated with hIVIG on days 10.5 and 17.5 | 36* | 0 | 0 |
| 3rd litter | No treatment | 26 | 3 | 11.5 |
| 4th litter | Treated with effector-silent mAb 26.4 on days 10.5 and 17.5 | 38* | 1 | 2.6 |
| 5th litter | No treatment | 25 | 2 | 8 |
| Pre-immunized BALB/c female bred with APLDQ male . | Treatment . | Total pups born from 4 females . | No. of dead or bleeding pups . | % Affected . |
|---|---|---|---|---|
| 1st litter | No treatment | 16 | 5 | 31 |
| 2nd litter | Treated with hIVIG on days 10.5 and 17.5 | 36* | 0 | 0 |
| 3rd litter | No treatment | 26 | 3 | 11.5 |
| 4th litter | Treated with effector-silent mAb 26.4 on days 10.5 and 17.5 | 38* | 1 | 2.6 |
| 5th litter | No treatment | 25 | 2 | 8 |
Pups in the % Affected column had both major and minor bleeding.
hIVIG, human IVIG.
There was a modest increase in litter size in females treated with either IVIG or mAb 26.4.