Current and planned trials for children with relapsed AML
| Target . | Agent(s) . | ID (www.clinicaltrials.gov) . | Study group . | Status . |
|---|---|---|---|---|
| BCL2 | Venetoclax | NCT03194932 | St Jude | Recruiting |
| BCL2 | Venetoclax | Pending | PedAL | Planned |
| BCL2 and XPO1 | Venetoclax and selinexor | Pending | St Jude | Planned |
| PD-1 | Nivolumab | NCT03825367 | TACL | Recruiting |
| IDH2 | Enasidenib | NCT04203316 | COG | Recruiting |
| NEDD8 | Pevonedistat | NCT03813147 | COG | Closed to accrual |
| MDM2 | Idasanutlin | NCT04029688 | Hoffmann-La Roche | Recruiting |
| Menin | SNDX-5613 | NCT04065399 | Syndax Pharmaceuticals | Recruiting |
| Menin | KO-539 | Pending | Kura Oncology | Planned |
| Mesothelin | Anetumab ravtansine | Pending | PedAL | Planned |
| E-selectin | Uproleselan | Pending | PedAL | Planned |
| CD123 | CART | NCT04318678 | St Jude | Recruiting |
| CD123 | Flotetuzumab | NCT04158739 | COG | Recruiting |
| CD123 | IMGN632 | Pending | PedAL | Planned |
| CD123 | Tagraxofusp | Pending | TACL | Planned |
| CD33 | CART | NCT03971799 | CIBMTR | Recruiting |
| Nonspecific | NK cells | NCT03068819 | Washington University | Recruiting |
| Target . | Agent(s) . | ID (www.clinicaltrials.gov) . | Study group . | Status . |
|---|---|---|---|---|
| BCL2 | Venetoclax | NCT03194932 | St Jude | Recruiting |
| BCL2 | Venetoclax | Pending | PedAL | Planned |
| BCL2 and XPO1 | Venetoclax and selinexor | Pending | St Jude | Planned |
| PD-1 | Nivolumab | NCT03825367 | TACL | Recruiting |
| IDH2 | Enasidenib | NCT04203316 | COG | Recruiting |
| NEDD8 | Pevonedistat | NCT03813147 | COG | Closed to accrual |
| MDM2 | Idasanutlin | NCT04029688 | Hoffmann-La Roche | Recruiting |
| Menin | SNDX-5613 | NCT04065399 | Syndax Pharmaceuticals | Recruiting |
| Menin | KO-539 | Pending | Kura Oncology | Planned |
| Mesothelin | Anetumab ravtansine | Pending | PedAL | Planned |
| E-selectin | Uproleselan | Pending | PedAL | Planned |
| CD123 | CART | NCT04318678 | St Jude | Recruiting |
| CD123 | Flotetuzumab | NCT04158739 | COG | Recruiting |
| CD123 | IMGN632 | Pending | PedAL | Planned |
| CD123 | Tagraxofusp | Pending | TACL | Planned |
| CD33 | CART | NCT03971799 | CIBMTR | Recruiting |
| Nonspecific | NK cells | NCT03068819 | Washington University | Recruiting |
CIBMTR, Center for International Blood and Marrow Transplant Research; PedAL, Pediatric Acute Leukemia; TACL, Therapeutic Advances in Childhood Leukemia Consortium.