Comparison of OS rates and median OS
| . | ZUMA-1 . | SCHOLAR-1 . | Ratio . |
|---|---|---|---|
| 12-mo OS rate (95% CI), %* | 71 (46-91) | 26 (22-32) | 2.7 (1.7-3.8) |
| 18-mo OS rate (95% CI), %* | 60 (37-83) | 23 (19-29) | 2.6 (1.5-3.9) |
| 24-mo OS rate (95% CI), %* | 54 (30-80) | 20 (16-26) | 2.7 (1.4-4.3) |
| Median OS (95% CI), mo* | 31.0 (11.5-NE) | 5.4 (4.6-6.3) | 25.6 (6.0-NE)† |
| Treatment difference, HR (95% CI)‡ | 0.27 (0.00-0.38) (73% reduction in the risk of death) | ||
| . | ZUMA-1 . | SCHOLAR-1 . | Ratio . |
|---|---|---|---|
| 12-mo OS rate (95% CI), %* | 71 (46-91) | 26 (22-32) | 2.7 (1.7-3.8) |
| 18-mo OS rate (95% CI), %* | 60 (37-83) | 23 (19-29) | 2.6 (1.5-3.9) |
| 24-mo OS rate (95% CI), %* | 54 (30-80) | 20 (16-26) | 2.7 (1.4-4.3) |
| Median OS (95% CI), mo* | 31.0 (11.5-NE) | 5.4 (4.6-6.3) | 25.6 (6.0-NE)† |
| Treatment difference, HR (95% CI)‡ | 0.27 (0.00-0.38) (73% reduction in the risk of death) | ||
HR, hazard ratio; NE, not estimable.
To control for confounding, the treatment-specific survival functions were obtained using augmented inverse-probability weighted complete-case estimators24 on the common support set for survival (ZUMA-1, N = 81; SCHOLAR-1, N = 331).
Difference between the 2 studies.
Stratification with regression-adjustment hazard ratio estimator on common support set for survival (ZUMA-1, N = 81; SCHOLAR-1, N = 331). This estimator was applied to the sensitivity common support set at 1 year and produced with similar results to the 1-year propensity–balanced analysis (data on file); however, it was not applied to the sensitivity common support set at 2 years.