Table 3. Available pharmacokinetic data... | American Society of Hematology

Table 3.

Available pharmacokinetic data of drugs in the ocular compartments

Reference	Drug	Route	n	Dose	Results
79	Cytarabine	IV	1	3 g/m²	At 90 min after perfusion: C (vitreous) = 22 μM; C (aqueous humor) = 31 μM; C (serum) = 11 μM
80	MTX*	IV	9	8 g/m² in a 4-h perfusion	At 4 h after perfusion: C (vitreous) > 1 μM
81	Ifosfamide	IV	6	1.5-2 g/m²	At the end of perfusion: C† (aqueous humor) = 0.32 − 1.56 μM in 6 patients
81	Trofosfamide	Oral	4	150-400 mg	C† (aqueous humor) = 7.2 μM in 1 patient 4 h after ingestion
59	MTX*	IVT	1	400 μg (4 mg/mL)	C (vitreous) ≈ 1 μM 5 d after IVT
60	Rituximab	IVT	16 rabbits	1 mg/0.1 mL	Half-life: 4.7 d Clearance from the aqueous humor: 1.2 mL/min

Reference	Drug	Route	n	Dose	Results
79	Cytarabine	IV	1	3 g/m²	At 90 min after perfusion: C (vitreous) = 22 μM; C (aqueous humor) = 31 μM; C (serum) = 11 μM
80	MTX*	IV	9	8 g/m² in a 4-h perfusion	At 4 h after perfusion: C (vitreous) > 1 μM
81	Ifosfamide	IV	6	1.5-2 g/m²	At the end of perfusion: C† (aqueous humor) = 0.32 − 1.56 μM in 6 patients
81	Trofosfamide	Oral	4	150-400 mg	C† (aqueous humor) = 7.2 μM in 1 patient 4 h after ingestion
59	MTX*	IVT	1	400 μg (4 mg/mL)	C (vitreous) ≈ 1 μM 5 d after IVT
60	Rituximab	IVT	16 rabbits	1 mg/0.1 mL	Half-life: 4.7 d Clearance from the aqueous humor: 1.2 mL/min

C, concentration.

The minimal effective tumoricidal (cytotoxic) level is 1 μM.

4-OH metabolites were dosed.