Association of rs1260326 and rs4665972 C alleles with intestinal gene expression
| Gene . | SNP ID . | Expression . | Intestinal phenotype induced by loss or decreased expression . | |||||
|---|---|---|---|---|---|---|---|---|
| Terminal ileum . | Transverse colon . | Sigmoid colon . | ||||||
| NES . | P . | NES . | P . | NES . | P . | |||
| GPN1 | rs1260326 | –0.163 | 4.0E-03 | –0.076 | 1.0E-02 | NS | NS | None |
| rs4665972 | –0.192 | 1.6E-03 | NS | NS | NS | NS | ||
| NPBP1 | rs1260326 | –0.214 | 2.2E-06 | –0.151 | 9.3E-09 | NS | NS | Detrimental |
| rs4665972 | –0.209 | 2.0E-05 | –0.144 | 6.7E-08 | NS | NS | ||
| PPM1G | rs1260326 | NS | NS | –0.065 | 9.1E-04 | –0.054 | 1.0E-02 | Detrimental |
| rs4665972 | NS | NS | –0.066 | 8.2E-04 | –0.059 | 7.0E-03 | ||
| SLC5A6 | rs1260326 | NR | NR | NR | NR | NR | NR | Detrimental |
| rs4665972 | NS | NS | NS | NS | –0.123 | 4.5E-04 | ||
| IFT172 | rs1260326* | NR | NR | –0.43 | 3.6E.09 | –0.47 | 2.1E-09 | None |
| rs4665972* | NR | NR | –0.41 | 1.7E-08 | –0.47 | 4.0E-09 | ||
| ATRIAD | rs1260326 | 0.143 | 3.7E-03 | 0.194 | 5.6E-08 | 0.114 | 4.1E-03 | None |
| rs4665972 | 0.166 | 1.8E-03 | 0.194 | 7.5E-08 | 0.119 | 2.9E-03 | ||
| C2ort16 | rs1260326 | 0.237 | 1.7E-03 | NS | NS | NS | NS | None |
| rs4665972 | 0.222 | 7.0E-03 | NS | NS | NS | NS | ||
| FNDC4 | rs1260326* | NS | NS | 0.27 | 1.9E-05 | NS | NS | Detrimental |
| rs4665972 | NS | NS | NS | NS | NS | NS | ||
| Gene . | SNP ID . | Expression . | Intestinal phenotype induced by loss or decreased expression . | |||||
|---|---|---|---|---|---|---|---|---|
| Terminal ileum . | Transverse colon . | Sigmoid colon . | ||||||
| NES . | P . | NES . | P . | NES . | P . | |||
| GPN1 | rs1260326 | –0.163 | 4.0E-03 | –0.076 | 1.0E-02 | NS | NS | None |
| rs4665972 | –0.192 | 1.6E-03 | NS | NS | NS | NS | ||
| NPBP1 | rs1260326 | –0.214 | 2.2E-06 | –0.151 | 9.3E-09 | NS | NS | Detrimental |
| rs4665972 | –0.209 | 2.0E-05 | –0.144 | 6.7E-08 | NS | NS | ||
| PPM1G | rs1260326 | NS | NS | –0.065 | 9.1E-04 | –0.054 | 1.0E-02 | Detrimental |
| rs4665972 | NS | NS | –0.066 | 8.2E-04 | –0.059 | 7.0E-03 | ||
| SLC5A6 | rs1260326 | NR | NR | NR | NR | NR | NR | Detrimental |
| rs4665972 | NS | NS | NS | NS | –0.123 | 4.5E-04 | ||
| IFT172 | rs1260326* | NR | NR | –0.43 | 3.6E.09 | –0.47 | 2.1E-09 | None |
| rs4665972* | NR | NR | –0.41 | 1.7E-08 | –0.47 | 4.0E-09 | ||
| ATRIAD | rs1260326 | 0.143 | 3.7E-03 | 0.194 | 5.6E-08 | 0.114 | 4.1E-03 | None |
| rs4665972 | 0.166 | 1.8E-03 | 0.194 | 7.5E-08 | 0.119 | 2.9E-03 | ||
| C2ort16 | rs1260326 | 0.237 | 1.7E-03 | NS | NS | NS | NS | None |
| rs4665972 | 0.222 | 7.0E-03 | NS | NS | NS | NS | ||
| FNDC4 | rs1260326* | NS | NS | 0.27 | 1.9E-05 | NS | NS | Detrimental |
| rs4665972 | NS | NS | NS | NS | NS | NS | ||
Expression results were obtained from the GTEx Portal, and intestinal phenotypes associated with loss or decreased expression were obtained from the Mouse Genome Database.18 Multi-tissue expression quantitative loci are reported except where indicated otherwise.
NES, normalized effect slope per C allele; NR, not reported; NS, not significant.
Single tissue splicing quantitative trait locus.