Table 2. Multivariable regression... | American Society of Hematology

Table 2.

Multivariable regression analyses

Variables in the model	OR/HR	95% CI	P value
Complete remission
Age: per 10-y increase	0.91	0.46-1.81	.79
WBC: per 50 × 10⁹/L increase	0.91	0.75-1.11	.36
Risk group*			.0064
Favorable vs intermediate	7.67	2.19-26.80	.0014
Adverse vs intermediate	0.66	0.23-1.85	.43
CALCRL expression: high vs low	0.57	0.25-1.29	.17
Overall survival
Age: per 10-y increase	1.29	0.93-1.79	.13
WBC: per 50 × 10⁹/L increase	0.98	0.88-1.09	.71
Risk group*			<.0001
Favorable vs intermediate	0.35	0.22-0.53	<.0001
Adverse vs intermediate	1.16	0.66-2.04	.61
CALCRL expression: high vs low	1.55	1.06-2.27	.025
Event-free survival
Age: per 10-y increase	1.11	0.85-1.45	.44
WBC: per 50 × 10⁹/L increase	1.03	0.94-1.12	.55
Risk group*			<.0001
Favorable vs intermediate	0.40	0.28-0.55	<.0001
Adverse vs intermediate	1.04	0.63-1.70	.89
CALCRL expression: high vs low	1.87	1.36-2.57	.0001
Cumulative incidence of relapse
Age: per 10-y increase	0.98	0.72-1.32	.87
WBC: per 50 × 10⁹/L increase	1.01	0.91-1.12	.83
Risk group*			<.0001
Favorable vs intermediate	0.46	0.32-0.64	<.0001
Adverse vs intermediate	0.79	0.44-1.41	.42
CALCRL expression: high vs low	2.10	1.49-2.96	<.0001

Variables in the model	OR/HR	95% CI	P value
Complete remission
Age: per 10-y increase	0.91	0.46-1.81	.79
WBC: per 50 × 10⁹/L increase	0.91	0.75-1.11	.36
Risk group*			.0064
Favorable vs intermediate	7.67	2.19-26.80	.0014
Adverse vs intermediate	0.66	0.23-1.85	.43
CALCRL expression: high vs low	0.57	0.25-1.29	.17
Overall survival
Age: per 10-y increase	1.29	0.93-1.79	.13
WBC: per 50 × 10⁹/L increase	0.98	0.88-1.09	.71
Risk group*			<.0001
Favorable vs intermediate	0.35	0.22-0.53	<.0001
Adverse vs intermediate	1.16	0.66-2.04	.61
CALCRL expression: high vs low	1.55	1.06-2.27	.025
Event-free survival
Age: per 10-y increase	1.11	0.85-1.45	.44
WBC: per 50 × 10⁹/L increase	1.03	0.94-1.12	.55
Risk group*			<.0001
Favorable vs intermediate	0.40	0.28-0.55	<.0001
Adverse vs intermediate	1.04	0.63-1.70	.89
CALCRL expression: high vs low	1.87	1.36-2.57	.0001
Cumulative incidence of relapse
Age: per 10-y increase	0.98	0.72-1.32	.87
WBC: per 50 × 10⁹/L increase	1.01	0.91-1.12	.83
Risk group*			<.0001
Favorable vs intermediate	0.46	0.32-0.64	<.0001
Adverse vs intermediate	0.79	0.44-1.41	.42
CALCRL expression: high vs low	2.10	1.49-2.96	<.0001

ORs greater or less than 1.0 indicate higher or lower CR rates, respectively, for the first category listed. HRs greater or less than 1.0 indicate an increased or decreased risk, respectively, of an event for the first category listed.

OR, odds ratio.

Risk groups were defined as described¹⁹ as favorable [t(8;21), inv(16)/t(16;16), NPM1 or CEBPA mutations in the absence of FLT3-ITD], adverse [-5/del(5q), -7, or high FLT3-ITD allelic ratio], and intermediate (all other patients with available genetic data).

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