Cohort demographics, laboratory parameters, and cytogenetic variables
| . | MDS . | MDS-MPN/CMML . | MPN . | ICUS . | CCUS . |
|---|---|---|---|---|---|
| Mean (2.5th-97.5th percentile) | |||||
| Age, y | 69.0 (41.00-85.70) | 70.0 (43.00-85.86) | 62.2 (28.35-83.90) | 56.0 (22.44-84.55) | 68.4 (40.55-85.04) |
| WBC, 109/L | 5.8 (1.29-20.23) | 19.8 (2.27-84.83) | 15.5 (2.99-61.99) | 4.4 (1.80-10.71) | 4.7 (1.80-10.84) |
| Hemoglobin, g/dL | 10.1 (6.80-14.10) | 11.1 (7.00-15.39) | 12.6 (7.19-20.70) | 12.2 (7.10-16.09) | 11.9 (7.57-15.01) |
| Platelets, 1012/L | 183.1 (15.00-650.15) | 182.6 (15.00-735.75) | 362.5 (10.13-1069.30) | 159.8 (19.52-387.32) | 142.5 (18.10-350.50) |
| ANC, 109/L | 3.1 (0.27-12.07) | 9.4 (0.59-37.21) | 10.3 (1.34-42.70) | 2.5 (0.19-7.34) | 2.5 (0.52-7.45) |
| ALC, 109/L | 1.0 (0.04-3.63) | 2.6 (0.44-7.85) | 2.3 (0.31-6.54) | 1.5 (0.46-3.25) | 1.6 (0.45-3.92) |
| AMC, 109/L | 0.3 (0.00-1.50) | 4.8 (0.08-26.28) | 0.9 (0.00-4.40) | 0.4 (0.02-1.08) | 0.5 (0.07-1.38) |
| BM blast, % | 5.0 (0.00-17.00) | 5.5 (0.00-19.00) | 1.5 (0.00-6.70) | 1.6 (0.00-4.50) | 1.8 (0.00-4.60) |
| Peripheral blasts, 109/L | 0.3 (0.00-3.00) | 1.6 (0.00-12.00) | 1.4 (0.00-8.32) | 0.0 (0.00-0.00) | 0.0 (0.00-0.00) |
| Number (%) | |||||
| Female | 1005 (37.26) | 392 (14.53) | 89 (3.30) | 67 (2.48) | 57 (2.11) |
| Normal karyotype | 810 (30.03) | 103 (3.82) | 104 (3.86) | 44 (1.63) | 30 (1.11) |
| Chr 5 abnormality | 135 (5.01) | 6 (0.22) | 4 (0.15) | 0 (0.00) | 0 (0.00) |
| Chr 7 abnormality | 73 (2.71) | 18 (0.67) | 5 (0.19) | 0 (0.00) | 0 (0.00) |
| Complex karyotype | 105 (3.89) | 12 (0.44) | 5 (0.19) | 0 (0.00) | 1 (0.04) |
| P | |||||
| Age, y | reference | 0.043 | 5.04E-12 | 1.27E-17 | 0.948 |
| WBC, 109/L | reference | 5.47E-122 | 3.94E-49 | 0.13 | 0.579 |
| Hemoglobin, g/dL | reference | 7.32E-21 | 7.99E-19 | 3.13E-25 | 2.86E-17 |
| Platelets, 1012/L | reference | 0.245 | 4.60E-19 | 0.727 | 5.13E-01 |
| ANC, 109/L | reference | 2.28E-79 | 2.23E-54 | 0.552 | 5.06E-01 |
| ALC, 109/L | reference | 6.23E-115 | 2.78E-34 | 4.27E-19 | 7.75E-15 |
| AMC, 109/L | reference | 1.77E-194 | 3.03E-34 | 8.28E-15 | 1.58E-13 |
| BM blast % | reference | 0.659 | 2.17E-24 | 1.43E-07 | 2.13E-05 |
| Peripheral blasts, 109/L | reference | 6.35E-54 | 2.58E-43 | 0.08 | 1.09E-01 |
| Female | reference | 0.468 | 2.94E-08 | 0.000987 | 9.69E-01 |
| Normal karyotype | reference | 1.10E-45 | 0.819 | 2.77E-05 | 2.00E-03 |
| Chr 5 abnormality | reference | 3.26E-10 | 0.001 | 0.000666 | 7.00E-03 |
| Chr 7 abnormality | reference | 0.118 | 0.199 | 0.019 | 6.90E-02 |
| Complex karyotype | reference | 2.89E-05 | 0.026 | 0.003 | 6.10E-02 |
| . | MDS . | MDS-MPN/CMML . | MPN . | ICUS . | CCUS . |
|---|---|---|---|---|---|
| Mean (2.5th-97.5th percentile) | |||||
| Age, y | 69.0 (41.00-85.70) | 70.0 (43.00-85.86) | 62.2 (28.35-83.90) | 56.0 (22.44-84.55) | 68.4 (40.55-85.04) |
| WBC, 109/L | 5.8 (1.29-20.23) | 19.8 (2.27-84.83) | 15.5 (2.99-61.99) | 4.4 (1.80-10.71) | 4.7 (1.80-10.84) |
| Hemoglobin, g/dL | 10.1 (6.80-14.10) | 11.1 (7.00-15.39) | 12.6 (7.19-20.70) | 12.2 (7.10-16.09) | 11.9 (7.57-15.01) |
| Platelets, 1012/L | 183.1 (15.00-650.15) | 182.6 (15.00-735.75) | 362.5 (10.13-1069.30) | 159.8 (19.52-387.32) | 142.5 (18.10-350.50) |
| ANC, 109/L | 3.1 (0.27-12.07) | 9.4 (0.59-37.21) | 10.3 (1.34-42.70) | 2.5 (0.19-7.34) | 2.5 (0.52-7.45) |
| ALC, 109/L | 1.0 (0.04-3.63) | 2.6 (0.44-7.85) | 2.3 (0.31-6.54) | 1.5 (0.46-3.25) | 1.6 (0.45-3.92) |
| AMC, 109/L | 0.3 (0.00-1.50) | 4.8 (0.08-26.28) | 0.9 (0.00-4.40) | 0.4 (0.02-1.08) | 0.5 (0.07-1.38) |
| BM blast, % | 5.0 (0.00-17.00) | 5.5 (0.00-19.00) | 1.5 (0.00-6.70) | 1.6 (0.00-4.50) | 1.8 (0.00-4.60) |
| Peripheral blasts, 109/L | 0.3 (0.00-3.00) | 1.6 (0.00-12.00) | 1.4 (0.00-8.32) | 0.0 (0.00-0.00) | 0.0 (0.00-0.00) |
| Number (%) | |||||
| Female | 1005 (37.26) | 392 (14.53) | 89 (3.30) | 67 (2.48) | 57 (2.11) |
| Normal karyotype | 810 (30.03) | 103 (3.82) | 104 (3.86) | 44 (1.63) | 30 (1.11) |
| Chr 5 abnormality | 135 (5.01) | 6 (0.22) | 4 (0.15) | 0 (0.00) | 0 (0.00) |
| Chr 7 abnormality | 73 (2.71) | 18 (0.67) | 5 (0.19) | 0 (0.00) | 0 (0.00) |
| Complex karyotype | 105 (3.89) | 12 (0.44) | 5 (0.19) | 0 (0.00) | 1 (0.04) |
| P | |||||
| Age, y | reference | 0.043 | 5.04E-12 | 1.27E-17 | 0.948 |
| WBC, 109/L | reference | 5.47E-122 | 3.94E-49 | 0.13 | 0.579 |
| Hemoglobin, g/dL | reference | 7.32E-21 | 7.99E-19 | 3.13E-25 | 2.86E-17 |
| Platelets, 1012/L | reference | 0.245 | 4.60E-19 | 0.727 | 5.13E-01 |
| ANC, 109/L | reference | 2.28E-79 | 2.23E-54 | 0.552 | 5.06E-01 |
| ALC, 109/L | reference | 6.23E-115 | 2.78E-34 | 4.27E-19 | 7.75E-15 |
| AMC, 109/L | reference | 1.77E-194 | 3.03E-34 | 8.28E-15 | 1.58E-13 |
| BM blast % | reference | 0.659 | 2.17E-24 | 1.43E-07 | 2.13E-05 |
| Peripheral blasts, 109/L | reference | 6.35E-54 | 2.58E-43 | 0.08 | 1.09E-01 |
| Female | reference | 0.468 | 2.94E-08 | 0.000987 | 9.69E-01 |
| Normal karyotype | reference | 1.10E-45 | 0.819 | 2.77E-05 | 2.00E-03 |
| Chr 5 abnormality | reference | 3.26E-10 | 0.001 | 0.000666 | 7.00E-03 |
| Chr 7 abnormality | reference | 0.118 | 0.199 | 0.019 | 6.90E-02 |
| Complex karyotype | reference | 2.89E-05 | 0.026 | 0.003 | 6.10E-02 |
ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; BM, bone marrow; Chr, chromosome; WBC , white blood cell.