Median OS and HR of death for various cohorts
| Cohort . | Median OS (mo) . | 95% CI . | Univariable . | Multivariable* . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of events/total no. of patients . | CNS vs target . | Wald P . | No. of events/total No. . | CNS vs target . | Wald P . | |||||
| HR . | 95% CI . | HR . | 95% CI . | |||||||
| CNS involvement | 11.4 | 7.2-17.7 | 32/36 | — | — | 30/34 | — | |||
| EMD but no CNS involvement | 11.3 | 10.4-12.8 | 621/733 | 1.07 | 0.75-1.53 | .70 | 564/660 | 0.96 | 0.66-1.41 | .84 |
| No EMD | 12.7 | 12.1-13.7 | 1972/2471 | 1.22 | 0.86-1.74 | .26 | 1793/2258 | 1.19 | 0.77-1.84 | .44 |
| Cohort . | Median OS (mo) . | 95% CI . | Univariable . | Multivariable* . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of events/total no. of patients . | CNS vs target . | Wald P . | No. of events/total No. . | CNS vs target . | Wald P . | |||||
| HR . | 95% CI . | HR . | 95% CI . | |||||||
| CNS involvement | 11.4 | 7.2-17.7 | 32/36 | — | — | 30/34 | — | |||
| EMD but no CNS involvement | 11.3 | 10.4-12.8 | 621/733 | 1.07 | 0.75-1.53 | .70 | 564/660 | 0.96 | 0.66-1.41 | .84 |
| No EMD | 12.7 | 12.1-13.7 | 1972/2471 | 1.22 | 0.86-1.74 | .26 | 1793/2258 | 1.19 | 0.77-1.84 | .44 |
All tests used Cox proportional hazards model.
Multivariable models were adjusted for age, sex, ECOG PS (0 vs 1 vs 2-4), marrow blasts, log-transformed WBC and platelet values, registration year, the number of EMD sites (0 [if applicable] vs 1 vs 2-6), cytogenetics (favorable vs intermediate vs unfavorable vs undetermined vs unknown), CR to induction treatment (no vs yes), and the EMD involvement (no vs yes, if applicable).