Association of markers of inflammation and endothelial activation across all children with severe anemia and P falciparum parasitemia
| . | N obs, n event . | HR . | 95% CI . | P* . | HR, adjusted for age and Hb genotype . | 95% CI, adjusted for age and Hb genotype . | P* . |
|---|---|---|---|---|---|---|---|
| Risk of death or readmission† | |||||||
| Angpt-2, pg/mL | 186, 49 | 1.45 | 0.77, 2.72 | .25 | 1.48 | 0.75, 2.92 | .25 |
| TNF-α, pg/mL | 212, 57 | 0.54 | 0.36, 0.81 | .003 | 0.55 | 0.36, 0.83 | .004 |
| l-arg/ADMA ratio | 165, 48 | 2.24 | 0.56, 8.91 | .25 | 2.67 | 0.64, 11.1 | .18 |
| Risk of malaria outpatient visit† | |||||||
| Angpt-2, pg/mL | 186, 81 | 1.83 | 1.09, 3.06 | .02 | 2.03 | 1.14, 3.59 | .016 |
| TNF-α, pg/mL | 212, 88 | 1.29 | 0.81, 2.06 | .28 | 1.33 | 0.82, 2.15 | .25 |
| l-arg/ADMA ratio | 165, 75 | 1.44 | 0.46, 4.47 | .53 | 1.77 | 0.55, 5.72 | .34 |
| . | N obs, n event . | HR . | 95% CI . | P* . | HR, adjusted for age and Hb genotype . | 95% CI, adjusted for age and Hb genotype . | P* . |
|---|---|---|---|---|---|---|---|
| Risk of death or readmission† | |||||||
| Angpt-2, pg/mL | 186, 49 | 1.45 | 0.77, 2.72 | .25 | 1.48 | 0.75, 2.92 | .25 |
| TNF-α, pg/mL | 212, 57 | 0.54 | 0.36, 0.81 | .003 | 0.55 | 0.36, 0.83 | .004 |
| l-arg/ADMA ratio | 165, 48 | 2.24 | 0.56, 8.91 | .25 | 2.67 | 0.64, 11.1 | .18 |
| Risk of malaria outpatient visit† | |||||||
| Angpt-2, pg/mL | 186, 81 | 1.83 | 1.09, 3.06 | .02 | 2.03 | 1.14, 3.59 | .016 |
| TNF-α, pg/mL | 212, 88 | 1.29 | 0.81, 2.06 | .28 | 1.33 | 0.82, 2.15 | .25 |
| l-arg/ADMA ratio | 165, 75 | 1.44 | 0.46, 4.47 | .53 | 1.77 | 0.55, 5.72 | .34 |
Association of markers of inflammation and endothelial activation associated with SCA and risk of readmission or death and risk of malarial outpatient visit within 24 months across all children with severe anemia and P falciparum parasitemia.
N obs, number observed.
Significant P values in bold, determined by FDR = 0.05.
Cox regression is based on log10 transformation of biomarkers, so HR is increase in outcome for each log10 increase in biomarker.