Univariate and multivariable analysis of induction failure
| Variable . | Multivariable analysis, n = 227 . | Model selection . | Univariate analysis . | Evaluable patients, n . | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | ||
| PS29MRCdic | 3.47 (1.65-7.39) | 1.09 × 10−3 | 3.54 (1.74-7.33) | .00054 | 4.81 (2.95-7.93) | 4.15 × 10−10 | 351 |
| Retrained response LSC17 | 1.00 (1.00-1.00) | .65 | 1.001 (1.000-1.002) | .046 | 360 | ||
| Age continuous | 1.03 (1.00-1.06) | .044 | 1.03 (1.00-1.05) | .043 | 1.04 (1.02-1.06) | 1.37 × 10−4 | 375 |
| Secondary AML | 1.06 (0.45-2.43) | .89 | 1.70 (0.96-2.94) | .063 | 375 | ||
| NPM1mut | 0.81 (0.34-1.93) | .64 | 0.49 (0.29-0.79) | 4.80 × 10−3 | 372 | ||
| RUNX1mut | 1.27 (0.46-3.44) | .64 | 2.58 (1.24-5.35) | .011 | 238 | ||
| TP53mut | 0.67 (0.16-2.75) | .58 | 2.62 (0.93-7.43) | .065 | 237 | ||
| ASXL1mut | 0.97 (0.34-2.75) | .96 | 2.21 (0.98-4.87) | .051 | 237 | ||
| ELN-2017fav | 0.41 (0.12-1.39) | .15 | 0.33 (0.13-0.81) | .016 | 0.17 (0.09-0.32) | 5.72 × 10−8 | 319 |
| ELN-2017int | 0.94 (0.33-2.70) | .91 | 0.88 (0.41-1.92) | .75 | 0.50 (0.26-0.94) | .033 | 319 |
| Variable . | Multivariable analysis, n = 227 . | Model selection . | Univariate analysis . | Evaluable patients, n . | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | ||
| PS29MRCdic | 3.47 (1.65-7.39) | 1.09 × 10−3 | 3.54 (1.74-7.33) | .00054 | 4.81 (2.95-7.93) | 4.15 × 10−10 | 351 |
| Retrained response LSC17 | 1.00 (1.00-1.00) | .65 | 1.001 (1.000-1.002) | .046 | 360 | ||
| Age continuous | 1.03 (1.00-1.06) | .044 | 1.03 (1.00-1.05) | .043 | 1.04 (1.02-1.06) | 1.37 × 10−4 | 375 |
| Secondary AML | 1.06 (0.45-2.43) | .89 | 1.70 (0.96-2.94) | .063 | 375 | ||
| NPM1mut | 0.81 (0.34-1.93) | .64 | 0.49 (0.29-0.79) | 4.80 × 10−3 | 372 | ||
| RUNX1mut | 1.27 (0.46-3.44) | .64 | 2.58 (1.24-5.35) | .011 | 238 | ||
| TP53mut | 0.67 (0.16-2.75) | .58 | 2.62 (0.93-7.43) | .065 | 237 | ||
| ASXL1mut | 0.97 (0.34-2.75) | .96 | 2.21 (0.98-4.87) | .051 | 237 | ||
| ELN-2017fav | 0.41 (0.12-1.39) | .15 | 0.33 (0.13-0.81) | .016 | 0.17 (0.09-0.32) | 5.72 × 10−8 | 319 |
| ELN-2017int | 0.94 (0.33-2.70) | .91 | 0.88 (0.41-1.92) | .75 | 0.50 (0.26-0.94) | .033 | 319 |
fav, favorable risk; int, intermediate risk; mut, mutated; P-values marked in bold indicate numbers that are significant (P < .05).