Table 3.

Univariate and multivariable analysis of induction failure among older patients

VariableMultivariable analysis, n = 82Univariate analysisEvaluable patients, n
OR (95% CI)POR (95% CI)P
PS29MRCdic 4.41 (1.55-13.41) 6.62 × 10−3 5.26 (2.72-10.46) 1.25 × 10−6 145 
Retrained response LSC17 1.00 (1.00-1.00) .39 1.00 (1.00-1.00) .12 152 
Age continuous 1.01 (0.91-1.11) .90 1.01 (0.96-1.07) .60 161 
Secondary AML 0.68 (0.22-1.93) .48 1.25 (0.62-2.47) .53 161 
NPM1mut 0.76 (0.22-2.76) .67 0.31 (0.15-0.60) 7.47 × 10−4 159 
RUNX1mut 1.50 (0.36-6.46) .58 1.91 (0.71-5.12) .19 91 
TP53mut 0.58 (0.08-3.97) .58 1.44 (0.39-5.11) .57 90 
ASXL1mut 2.31 (0.54-10.44) .26 2.12 (0.78-5.85) .14 90 
ELN-2017fav 1.06 (0.15-7.39) .95 0.20 (0.08-0.44) 1.40 × 10−4 128 
ELN-2017int 2.14 (0.42-11.18) .36 0.81 (0.33-1.98) .65 128 
VariableMultivariable analysis, n = 82Univariate analysisEvaluable patients, n
OR (95% CI)POR (95% CI)P
PS29MRCdic 4.41 (1.55-13.41) 6.62 × 10−3 5.26 (2.72-10.46) 1.25 × 10−6 145 
Retrained response LSC17 1.00 (1.00-1.00) .39 1.00 (1.00-1.00) .12 152 
Age continuous 1.01 (0.91-1.11) .90 1.01 (0.96-1.07) .60 161 
Secondary AML 0.68 (0.22-1.93) .48 1.25 (0.62-2.47) .53 161 
NPM1mut 0.76 (0.22-2.76) .67 0.31 (0.15-0.60) 7.47 × 10−4 159 
RUNX1mut 1.50 (0.36-6.46) .58 1.91 (0.71-5.12) .19 91 
TP53mut 0.58 (0.08-3.97) .58 1.44 (0.39-5.11) .57 90 
ASXL1mut 2.31 (0.54-10.44) .26 2.12 (0.78-5.85) .14 90 
ELN-2017fav 1.06 (0.15-7.39) .95 0.20 (0.08-0.44) 1.40 × 10−4 128 
ELN-2017int 2.14 (0.42-11.18) .36 0.81 (0.33-1.98) .65 128 

fav, favorable risk; int, intermediate risk; mut, mutated; P-values marked in bold indicate numbers that are significant (P < .05).

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