Table 2. Prognostic relevance of low... | American Society of Hematology

Table 2.

Prognostic relevance of low expression of miR-497/195

	χ²P	HR (relapse)	95% CI
Expression of miR-497/195 below median	.002	12.4	2.5-62.3
Age 10 years or older at diagnosis	.21	0.211	0.018-2.423
WBC 50 g/L or higher	.21	3.103	0.520-18.520
IKZF1^plus	.64	2.031	0.106-38.906

	χ²P	HR (relapse)	95% CI
Expression of miR-497/195 below median	.002	12.4	2.5-62.3
Age 10 years or older at diagnosis	.21	0.211	0.018-2.423
WBC 50 g/L or higher	.21	3.103	0.520-18.520
IKZF1^plus	.64	2.031	0.106-38.906

Multivariate analysis on incidence of relapse with a Fine and Gray model (N = 52) was performed. Risk factors included are miR-497/195 expression below median (log₁₀ miR-497 + log₁₀ miR-195 < –0.5), age at diagnosis 10 years or older, white blood cell count (WBC) in peripheral blood at diagnosis 50 g/L or higher, IKZF1^plus (deletion of IKZF1 co-occurring with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG deletion³⁸).

CI, confidence interval; HR, hazard ratio.

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