Calpain cleavages in human talin 1 (UniProt Q9Y490)
| P4P3P2P1 . | P′1P′2P′3P′4 . | Exp, n . | Pep, n . | Comments . |
|---|---|---|---|---|
| FQVG(466) | (467)SMPP | 4 | 5 | Separates head and rod domains |
| AVGC(575) | (576)AVTT | 2 | 1 | Cleavage adjoins VB helix 4 of R1 |
| ACTK(721) | (722)VVAP | 2 | 2 | Cleavage adjoins VB helix 6 of R2 |
| DLVN(838) | (839)AIKA | 4 | 2 | Cleaves within VBS11 of R3 |
| GLRM(899) | (900)ATNA | 4 | 2 | Cleavage adjoins VB helix 12 of R3 |
| ARAL(1620) | (1621)AVNP | 2 | 1 | Cleavage adjoins VB helix 36 of R7 |
| ATAK(2188) | (2189)AVAA | 4 | 2 | Cleavage adjoins VB helix 50 |
| VKEK(2493) | (2494)MVGG | 4 | 5 | Removes dimerization helix |
| P4P3P2P1 . | P′1P′2P′3P′4 . | Exp, n . | Pep, n . | Comments . |
|---|---|---|---|---|
| FQVG(466) | (467)SMPP | 4 | 5 | Separates head and rod domains |
| AVGC(575) | (576)AVTT | 2 | 1 | Cleavage adjoins VB helix 4 of R1 |
| ACTK(721) | (722)VVAP | 2 | 2 | Cleavage adjoins VB helix 6 of R2 |
| DLVN(838) | (839)AIKA | 4 | 2 | Cleaves within VBS11 of R3 |
| GLRM(899) | (900)ATNA | 4 | 2 | Cleavage adjoins VB helix 12 of R3 |
| ARAL(1620) | (1621)AVNP | 2 | 1 | Cleavage adjoins VB helix 36 of R7 |
| ATAK(2188) | (2189)AVAA | 4 | 2 | Cleavage adjoins VB helix 50 |
| VKEK(2493) | (2494)MVGG | 4 | 5 | Removes dimerization helix |
Exp, number of biological replicates where calpain cleavage has taken place; Pep, number of unique peptides that was seen in all of the experiments.