Table 2.

Multivariable analysis using competing risk regression on CIR and Cox proportional hazards regression on OS

VariableCompeting risk regression on CIRCox proportional hazards regression on OS
HR95% CIPHR95% CIP
RNA-seq risk stratification       
 Low* 1.0   1.0   
 Intermediate 2.89 1.26-6.61 .01 14.34 1.67-123.53 .02 
 High 4.85   1.94-12.10  7.2 × 10−4 31.63   3.71-296.32 1.6 × 10−3 
Age, y       
 1-10* 1.0   1.0   
 <1 0.72 0.26-2.00 .53 1.06 0.21-5.50 .94 
 ≥10 0.74 0.28-1.97 .54 3.24 1.03-10.17 .04 
Sex       
 Female*   1.0    1.0   
 Male 1.50 0.77-2.95 .23 1.36 0.46-3.98 .58 
WBC       
 <50 × 109/L* 1.0   1.0   
 ≥50 × 109/L 1.48 0.77-2.84 .24 1.56 0.59-4.15 .37 
Day 33 MRD       
 ≤1 × 10−4*   1.0   1.0   
 1 × 10−4 to 1 × 10−2 2.02 0.91-4.48 .08 2.44 0.71-8.46 .16 
 ≥1 × 10−2   8.73  3.57-21.32  2.0 × 10−6 3.31   0.91-12.07 .07 
Protocol       
 MS2003* 1.0   1.0   
 MS2010 0.46 0.23-0.93 .03 0.38 0.12-1.25 .11 
VariableCompeting risk regression on CIRCox proportional hazards regression on OS
HR95% CIPHR95% CIP
RNA-seq risk stratification       
 Low* 1.0   1.0   
 Intermediate 2.89 1.26-6.61 .01 14.34 1.67-123.53 .02 
 High 4.85   1.94-12.10  7.2 × 10−4 31.63   3.71-296.32 1.6 × 10−3 
Age, y       
 1-10* 1.0   1.0   
 <1 0.72 0.26-2.00 .53 1.06 0.21-5.50 .94 
 ≥10 0.74 0.28-1.97 .54 3.24 1.03-10.17 .04 
Sex       
 Female*   1.0    1.0   
 Male 1.50 0.77-2.95 .23 1.36 0.46-3.98 .58 
WBC       
 <50 × 109/L* 1.0   1.0   
 ≥50 × 109/L 1.48 0.77-2.84 .24 1.56 0.59-4.15 .37 
Day 33 MRD       
 ≤1 × 10−4*   1.0   1.0   
 1 × 10−4 to 1 × 10−2 2.02 0.91-4.48 .08 2.44 0.71-8.46 .16 
 ≥1 × 10−2   8.73  3.57-21.32  2.0 × 10−6 3.31   0.91-12.07 .07 
Protocol       
 MS2003* 1.0   1.0   
 MS2010 0.46 0.23-0.93 .03 0.38 0.12-1.25 .11 
*

Reference group.

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