Prognostic factors on relapse, RFS, and OS in multivariate analyses in the whole cohort and AML risk according to ALFA classification
| . | Risk of relapse . | RFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CSHR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| WT1 MRD | .0003 | .0002 | .018 | ||||||
| Low ratio | 1.0 | — | 1.0 | — | 1.0 | — | |||
| High ratio | 2.2 | 1.44-3.36 | 2.05 | 1.4-3 | 1.7 | 1.1-2.63 | |||
| Age effect for 1-y increase | 1.03 | 1.01-1.05 | .0032 | 1.03 | 1.01-1.04 | .0015 | 1.04 | 1.02-1.06 | .0002 |
| WBC effect for 1 × 109/L increase | 1.0 | 1-1.01 | .0011 | 1.0 | 1-1.01 | .0018 | 1.01 | 1-1.01 | .0002 |
| ALFA risk classification | <.0001 | <.0001 | <.0001 | ||||||
| Favorable | 1 | — | 1 | — | 1 | — | |||
| Intermediate | 3.23 | 1.69-6.14 | 2.53 | 1.5-4.25 | 2.99 | 1.54-5.83 | |||
| Unfavorable | 4.5 | 2.28-8.9 | 3.4 | 1.96-5.9 | 4.79 | 2.39-9.57 | |||
| . | Risk of relapse . | RFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CSHR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| WT1 MRD | .0003 | .0002 | .018 | ||||||
| Low ratio | 1.0 | — | 1.0 | — | 1.0 | — | |||
| High ratio | 2.2 | 1.44-3.36 | 2.05 | 1.4-3 | 1.7 | 1.1-2.63 | |||
| Age effect for 1-y increase | 1.03 | 1.01-1.05 | .0032 | 1.03 | 1.01-1.04 | .0015 | 1.04 | 1.02-1.06 | .0002 |
| WBC effect for 1 × 109/L increase | 1.0 | 1-1.01 | .0011 | 1.0 | 1-1.01 | .0018 | 1.01 | 1-1.01 | .0002 |
| ALFA risk classification | <.0001 | <.0001 | <.0001 | ||||||
| Favorable | 1 | — | 1 | — | 1 | — | |||
| Intermediate | 3.23 | 1.69-6.14 | 2.53 | 1.5-4.25 | 2.99 | 1.54-5.83 | |||
| Unfavorable | 4.5 | 2.28-8.9 | 3.4 | 1.96-5.9 | 4.79 | 2.39-9.57 | |||
WT1 MRD high ratio: WT1/100ABL >2.5% in BM or >0.5% in PB; WT1 MRD low ratio: patients with WT1/100ABL <2.5% in BM or <0.5% in PB.