Summary of PANTHER analysis of shared and gene-specific dysregulated genes
| Gene sets* . | No. of genes . | No. of biological processes and/or molecular functions† . | Most significant FDR . | Predominant functions . |
|---|---|---|---|---|
| Shared, FANC, SBDS, and DKC1, up | 26 | 7 | 4.88E-11 | Ribosome constituent, translation |
| Shared, FANC, SBDS, and DKC1, down | 1 | 0 | NA | NA |
| FANC-specific, up | 554 | 0 | NA | NA |
| FANC-specific, down | 142 | 19 | 9.0E-65 | Antigen binding, complement activation |
| SBDS-specific, up | 152 | 1 | 1.59E-05 | Neutrophil degranulation |
| SBDS-specific, down | 85 | 0 | NA | NA |
| DKC1-specific, up | 182 | 28 | 2.74E-18 | Ribosome constituent, RNA binding, complement activation |
| DKC1-specific, down | 148 | 0 | NA | NA |
| Gene sets* . | No. of genes . | No. of biological processes and/or molecular functions† . | Most significant FDR . | Predominant functions . |
|---|---|---|---|---|
| Shared, FANC, SBDS, and DKC1, up | 26 | 7 | 4.88E-11 | Ribosome constituent, translation |
| Shared, FANC, SBDS, and DKC1, down | 1 | 0 | NA | NA |
| FANC-specific, up | 554 | 0 | NA | NA |
| FANC-specific, down | 142 | 19 | 9.0E-65 | Antigen binding, complement activation |
| SBDS-specific, up | 152 | 1 | 1.59E-05 | Neutrophil degranulation |
| SBDS-specific, down | 85 | 0 | NA | NA |
| DKC1-specific, up | 182 | 28 | 2.74E-18 | Ribosome constituent, RNA binding, complement activation |
| DKC1-specific, down | 148 | 0 | NA | NA |
Gene lists are provided in supplemental Table 5, details of the 26 shared upregulated genes are provided in supplemental Table 6, and the lists of GO terms for biological processes and molecular function are provided in supplemental Table 7.
NA, none available.
Differentially expressed, FDR < 0.05.
The most stringent GO terms for biological process or molecular function, FDR < 0.001.