Characteristics of the patients at baseline
| Characteristic . | Total (n = 50) . | t(4;11) (n = 42) . | Other KMT2A-r (n = 8) . | Non-KMT2-r (n = 1052) . |
|---|---|---|---|---|
| Age (y) | 45 [18-78] | 45 [18-74] | 42 [19-78] | 44 [18-85] |
| <40 y | 21 (42) | 17 (40) | 4 (50) | 451 (43) |
| Gender (male) | 19 (38) | 16 (38) | 3 (38) | 613 (58) |
| Hematologic parameters | ||||
| WBC (×109/L) | 109.0 [0.5-1573.0] | 111.8 [0.5-1573.0] | 37.0 [4.6-423.1] | 8.0 [0.2-1037] |
| WBC ≥ 30 ×109/L | 39 (78) | 35 (83) | 4 (50) | 303 (29) |
| WBC ≥ 100 ×109/L | 29 (58) | 26 (62) | 3 (38) | 132 (13) |
| Hb (g/dL) | 9.4 [3.6-16.5] | 9.4 [3.6-13.5] | 9.0 [5.9-16.5] | 9.3 [3.5-16.4] |
| Plt (×109/L) | 43 [6-442] | 43 [7-442] | 50 [6-191] | 45 [0-626] |
| Cell lineage | ||||
| B-cell ALL | 44/45 (98) | 38/39 (97) | 6/6 (100) | 913 (87) |
| T-cell ALL | 1/45 (2) | 1/39 (3) | 0/6 (0) | 138 (13) |
| Immunophenotype* | ||||
| CD19+ (≥70% cells) | 40/43 (93) | 36/38 (95) | 4/5 (80) | 806/971 (83) |
| CD10+ (≥20% cells) | 1/47 (2) | 1/41 (2) | 0/6 (0) | 414/561 (74) |
| CD20+ (≥20% cells) | 0/45 (0) | 0/39 (0) | 0/6 (0) | 467/944 (49) |
| CD22+ (≥70% cells) | 13/37 (35) | 13/33 (83) | 0/4 (0) | 620/873 (71) |
| Additional abnormalities | ||||
| Overall | 15 (30) | 12 (26) | 3 (38) | NA |
| Isochromosome 7q | 3 (6) | 3 (7) | 0 (0) | NA |
| +X | 2 (4) | 2 (5) | 0 (0) | NA |
| Characteristic . | Total (n = 50) . | t(4;11) (n = 42) . | Other KMT2A-r (n = 8) . | Non-KMT2-r (n = 1052) . |
|---|---|---|---|---|
| Age (y) | 45 [18-78] | 45 [18-74] | 42 [19-78] | 44 [18-85] |
| <40 y | 21 (42) | 17 (40) | 4 (50) | 451 (43) |
| Gender (male) | 19 (38) | 16 (38) | 3 (38) | 613 (58) |
| Hematologic parameters | ||||
| WBC (×109/L) | 109.0 [0.5-1573.0] | 111.8 [0.5-1573.0] | 37.0 [4.6-423.1] | 8.0 [0.2-1037] |
| WBC ≥ 30 ×109/L | 39 (78) | 35 (83) | 4 (50) | 303 (29) |
| WBC ≥ 100 ×109/L | 29 (58) | 26 (62) | 3 (38) | 132 (13) |
| Hb (g/dL) | 9.4 [3.6-16.5] | 9.4 [3.6-13.5] | 9.0 [5.9-16.5] | 9.3 [3.5-16.4] |
| Plt (×109/L) | 43 [6-442] | 43 [7-442] | 50 [6-191] | 45 [0-626] |
| Cell lineage | ||||
| B-cell ALL | 44/45 (98) | 38/39 (97) | 6/6 (100) | 913 (87) |
| T-cell ALL | 1/45 (2) | 1/39 (3) | 0/6 (0) | 138 (13) |
| Immunophenotype* | ||||
| CD19+ (≥70% cells) | 40/43 (93) | 36/38 (95) | 4/5 (80) | 806/971 (83) |
| CD10+ (≥20% cells) | 1/47 (2) | 1/41 (2) | 0/6 (0) | 414/561 (74) |
| CD20+ (≥20% cells) | 0/45 (0) | 0/39 (0) | 0/6 (0) | 467/944 (49) |
| CD22+ (≥70% cells) | 13/37 (35) | 13/33 (83) | 0/4 (0) | 620/873 (71) |
| Additional abnormalities | ||||
| Overall | 15 (30) | 12 (26) | 3 (38) | NA |
| Isochromosome 7q | 3 (6) | 3 (7) | 0 (0) | NA |
| +X | 2 (4) | 2 (5) | 0 (0) | NA |
Data are presented as numbers with percentages in parentheses or medians with ranges in brackets.
Hb, hemoglobin; KMT2A-r, KMT2A rearranged/rearrangement; Plt, platelets.
Immunophenotype data are missing for some markers in some patients (7 are missing for CD19, 3 are missing for CD10, 5 are missing for CD20, and 13 are missing for CD22)