Table 2. Investigations in... | American Society of Hematology

Table 2.

Investigations in pregnancy-associated TMA

Test	TTP	CM-HUS	Pregnancy-related TMAs (eg, PE, HELLP, AFLP)
Hemoglobin	Reduced	Reduced	Reduced
Platelet count	Very reduced	Reduced	Reduced/very reduced
Reticulocytes	Increased	Increased	Normal/increased
Fragmentation on blood film	Yes +++	Yes ++	Yes +
Serum creatinine	Normal/increased	Increased	Normal/increased
Urine protein/creatinine ratio	Normal/increased	Increased	Increased
Coagulation screen	Normal	Normal	Normal (except AFLP; coagulation screen prolonged—decreased fibrinogen)
Bilirubin	Increased	Increased	Mild increase
ALT/AST	Normal	Normal	Increased
Alkaline phosphatase	Normal	Normal	Increased in HELLP and AFLP
Urate	Normal	Normal	Increased
C3/C4	Normal	Reduced C3 in some cases	Normal
ADAMTS-13	Severely reduced	Mildly reduced	Mildly reduced

Test	TTP	CM-HUS	Pregnancy-related TMAs (eg, PE, HELLP, AFLP)
Hemoglobin	Reduced	Reduced	Reduced
Platelet count	Very reduced	Reduced	Reduced/very reduced
Reticulocytes	Increased	Increased	Normal/increased
Fragmentation on blood film	Yes +++	Yes ++	Yes +
Serum creatinine	Normal/increased	Increased	Normal/increased
Urine protein/creatinine ratio	Normal/increased	Increased	Increased
Coagulation screen	Normal	Normal	Normal (except AFLP; coagulation screen prolonged—decreased fibrinogen)
Bilirubin	Increased	Increased	Mild increase
ALT/AST	Normal	Normal	Increased
Alkaline phosphatase	Normal	Normal	Increased in HELLP and AFLP
Urate	Normal	Normal	Increased
C3/C4	Normal	Reduced C3 in some cases	Normal
ADAMTS-13	Severely reduced	Mildly reduced	Mildly reduced

Note: the degree of involvement is demonstrated by an increasing number of +.