Definition of clinical entities associated with CH
| Clonal hematopoiesis of indeterminate potential (CHIP) |
| • Presence of somatic mutation(s) in gene(s) associated with hematologic malignancies |
| • Normal hemogram |
| • No clinical of pathological evidence of hematologic malignancy |
| Age-related clonal hematopoiesis (ARCH) |
| • Any CH associated with aging |
| Clonal cytopenia of undetermined significance (CCUS) |
| • Presence of somatic mutation(s) in gene(s) associated with hematologic malignancies |
| • Presence of clinically relevant and persistent cytopenia in 1 or more peripheral blood cell lineages |
| • Diagnostic criteria of myeloid neoplasm not fulfilled |
| • No other causes of cytopenia and molecular aberration |
| Idiopathic cytopenia of undetermined significance (ICUS) |
| • Presence of clinically relevant and persistent cytopenia in 1 or more peripheral blood cell lineages |
| • Not explained by any other disease |
| • Diagnostic criteria of myeloid neoplasm not fulfilled |
| Clonal hematopoiesis of indeterminate potential (CHIP) |
| • Presence of somatic mutation(s) in gene(s) associated with hematologic malignancies |
| • Normal hemogram |
| • No clinical of pathological evidence of hematologic malignancy |
| Age-related clonal hematopoiesis (ARCH) |
| • Any CH associated with aging |
| Clonal cytopenia of undetermined significance (CCUS) |
| • Presence of somatic mutation(s) in gene(s) associated with hematologic malignancies |
| • Presence of clinically relevant and persistent cytopenia in 1 or more peripheral blood cell lineages |
| • Diagnostic criteria of myeloid neoplasm not fulfilled |
| • No other causes of cytopenia and molecular aberration |
| Idiopathic cytopenia of undetermined significance (ICUS) |
| • Presence of clinically relevant and persistent cytopenia in 1 or more peripheral blood cell lineages |
| • Not explained by any other disease |
| • Diagnostic criteria of myeloid neoplasm not fulfilled |