Supportive care recommendations for oral chronic GVHD
| Mild to moderate mucosal disease |
| Localized application of high-potency topical corticosteroids Generalized application of upper mid-strength topical corticosteroid Topical analgesics |
| Moderate to severe mucosal disease |
| Localized application of upper mid-strength topical corticosteroids Topical application of tacrolimus 0.1% ointment Intralesional therapy with high-potency steroids for refractory lesions Topical application of cyclosporine rinses Oral phototherapy |
| Salivary gland disease |
| Home fluoride therapy Frequent water sipping and saliva substitutes Salivary stimulants (sugar-free gum, sugar-free candy) Sialogogues: cevimeline, pilocarpine |
| Mild to moderate mucosal disease |
| Localized application of high-potency topical corticosteroids Generalized application of upper mid-strength topical corticosteroid Topical analgesics |
| Moderate to severe mucosal disease |
| Localized application of upper mid-strength topical corticosteroids Topical application of tacrolimus 0.1% ointment Intralesional therapy with high-potency steroids for refractory lesions Topical application of cyclosporine rinses Oral phototherapy |
| Salivary gland disease |
| Home fluoride therapy Frequent water sipping and saliva substitutes Salivary stimulants (sugar-free gum, sugar-free candy) Sialogogues: cevimeline, pilocarpine |