Mechanisms that dampen immune response in the tumor microenvironment and corresponding immunotherapeutic approaches
| Mechanisms to evade immune response . | Immunotherapeutic approaches . |
|---|---|
| Loss of antigenicity of tumor cells (ex: loss of MHC, downregulation of costimulatory molecules) | CAR-T, BiTE |
| Increased expression of inhibitory ligands on tumor cells or in microenvironment | Immune checkpoint blockade |
| Suppressive immune populations in tumor microenvironment | CD47 blockade (experimental) |
| Mechanisms to evade immune response . | Immunotherapeutic approaches . |
|---|---|
| Loss of antigenicity of tumor cells (ex: loss of MHC, downregulation of costimulatory molecules) | CAR-T, BiTE |
| Increased expression of inhibitory ligands on tumor cells or in microenvironment | Immune checkpoint blockade |
| Suppressive immune populations in tumor microenvironment | CD47 blockade (experimental) |