Curaçao criteria for the clinical diagnosis of HHT12
| Telangiectases | Multiple, at characteristic sites |
| Lips, oral cavity, fingers, nose | |
| Epistaxis | Recurrent spontaneous nosebleeds |
| Visceral involvement | GI telangiectasia |
| Pulmonary AVM | |
| Hepatic AVM | |
| Cerebral VM | |
| Spinal AVM | |
| Family history | First-degree relative with known HHT |
| Parent, sibling, or child | |
| Definite if ≥3 criteria are present OR if pathogenic variant identified in known HHT gene | |
| Suspected if 2 criteria are present | |
| Unlikely if <2 criteria are present | |
| Telangiectases | Multiple, at characteristic sites |
| Lips, oral cavity, fingers, nose | |
| Epistaxis | Recurrent spontaneous nosebleeds |
| Visceral involvement | GI telangiectasia |
| Pulmonary AVM | |
| Hepatic AVM | |
| Cerebral VM | |
| Spinal AVM | |
| Family history | First-degree relative with known HHT |
| Parent, sibling, or child | |
| Definite if ≥3 criteria are present OR if pathogenic variant identified in known HHT gene | |
| Suspected if 2 criteria are present | |
| Unlikely if <2 criteria are present | |