Table 1.

PK characteristics of the HMAs

AgentBioavailability of single oral dose (% of parenteral)T1/2Tmax (range)Cmax in ng/mL (% coefficient of variation)
Azacitidine IV34,40  100% 4 h 0.5 h Similar to SQ 
Azacitidine SQ34,40  89% 4 h 0.5 h (0.2-1.1) 750 (54%) 
CC-48640,52  11% 0.5 h 1 h (0.47-2) 145 (64%) 
Decitabine IV35  100% 0.5 h 1 h 147 (49%) 
Decitabine PO41  3.9%-14.1% 0.36-0.93 h 0.5 h — 
C-DEC43  60% (55-65) D1; 106% (98-114) D5 1.5 h 1 h (0.3-3.0) 145 (55%) 
AgentBioavailability of single oral dose (% of parenteral)T1/2Tmax (range)Cmax in ng/mL (% coefficient of variation)
Azacitidine IV34,40  100% 4 h 0.5 h Similar to SQ 
Azacitidine SQ34,40  89% 4 h 0.5 h (0.2-1.1) 750 (54%) 
CC-48640,52  11% 0.5 h 1 h (0.47-2) 145 (64%) 
Decitabine IV35  100% 0.5 h 1 h 147 (49%) 
Decitabine PO41  3.9%-14.1% 0.36-0.93 h 0.5 h — 
C-DEC43  60% (55-65) D1; 106% (98-114) D5 1.5 h 1 h (0.3-3.0) 145 (55%) 
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