Cox proportional regression hazards model of factor on PFS, EFS, OS, Tox-DTD, and PDR
| . | PFS . | EFS . | OS . | Tox-DTD . | PDR . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age | 0.82 (0.57-1.18) | .296 | 0.83 (0.59-1.15) | .254 | 0.85 (0.54-1.35) | .496 | 0.91 (0.53-1.54) | .722 | 0.73 (0.45-1.18) | .201 |
| ECOG-PS | 2.43 (1.72-3.42) | <.001 | 2.63 (1.92-3.61) | <.001 | 3.90 (2.61-5.85) | <.001 | 3.30 (2.09-5.20) | <.001 | 1.52 (0.91-2.55) | .112 |
| CIRS6 | 1.48 (1.02-2.15) | .037 | 1.44 (1.03-2.00) | .033 | 1.01 (0.63-1.62) | .964 | 1.33 (0.80-2.21) | .270 | 1.12 (0.70-1.81) | .638 |
| CIRS3+ | 0.79 (0.52-1.19) | .261 | 1.03 (0.71-1.48) | .894 | 0.95 (0.58-1.56) | .844 | 1.54 (0.94-2.51) | .084 | 1.72 (1.08-2.75) | .024 |
| CCI | 1.10 (0.71-1.72) | .662 | 1.19 (0.79-1.78) | .416 | 1.37 (0.75-2.52) | .306 | 1.53 (0.72-3.25) | .268 | 3.88 (1.50-10.06) | .005 |
| Neutropenia | 1.70 (1.09-2.67) | .020 | 1.51 (1.001-2.27) | .049 | 1.72 (1.01-2.91) | .044 | 1.83 (1.04-3.22) | .038 | 1.08 (0.57-2.02) | .814 |
| CYP3A4 | 1.07 (0.66-1.76) | .780 | 1.26 (0.82-1.94) | .285 | 1.09 (0.59-2.03) | .784 | 1.15 (0.59-2.25) | .670 | 2.05 (1.24-3.41) | .005 |
| del(17p) and/or TP53mut | 2.19 (1.57-3.04) | <.001 | 1.78 (1.32-2.40) | <.001 | 2.06 (1.35-3.15) | <.001 | 1.59 (0.98-2.57) | .059 | 0.94 (0.60-1.48) | .800 |
| Lines of previous Tx | 1.85 (1.17-2.95) | .009 | 1.65 (1.10-2.48) | .015 | 2.73 (1.33-5.60) | .006 | 1.80 (0.97-3.34) | .064 | 1.32 (0.79-2.22) | .289 |
| . | PFS . | EFS . | OS . | Tox-DTD . | PDR . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age | 0.82 (0.57-1.18) | .296 | 0.83 (0.59-1.15) | .254 | 0.85 (0.54-1.35) | .496 | 0.91 (0.53-1.54) | .722 | 0.73 (0.45-1.18) | .201 |
| ECOG-PS | 2.43 (1.72-3.42) | <.001 | 2.63 (1.92-3.61) | <.001 | 3.90 (2.61-5.85) | <.001 | 3.30 (2.09-5.20) | <.001 | 1.52 (0.91-2.55) | .112 |
| CIRS6 | 1.48 (1.02-2.15) | .037 | 1.44 (1.03-2.00) | .033 | 1.01 (0.63-1.62) | .964 | 1.33 (0.80-2.21) | .270 | 1.12 (0.70-1.81) | .638 |
| CIRS3+ | 0.79 (0.52-1.19) | .261 | 1.03 (0.71-1.48) | .894 | 0.95 (0.58-1.56) | .844 | 1.54 (0.94-2.51) | .084 | 1.72 (1.08-2.75) | .024 |
| CCI | 1.10 (0.71-1.72) | .662 | 1.19 (0.79-1.78) | .416 | 1.37 (0.75-2.52) | .306 | 1.53 (0.72-3.25) | .268 | 3.88 (1.50-10.06) | .005 |
| Neutropenia | 1.70 (1.09-2.67) | .020 | 1.51 (1.001-2.27) | .049 | 1.72 (1.01-2.91) | .044 | 1.83 (1.04-3.22) | .038 | 1.08 (0.57-2.02) | .814 |
| CYP3A4 | 1.07 (0.66-1.76) | .780 | 1.26 (0.82-1.94) | .285 | 1.09 (0.59-2.03) | .784 | 1.15 (0.59-2.25) | .670 | 2.05 (1.24-3.41) | .005 |
| del(17p) and/or TP53mut | 2.19 (1.57-3.04) | <.001 | 1.78 (1.32-2.40) | <.001 | 2.06 (1.35-3.15) | <.001 | 1.59 (0.98-2.57) | .059 | 0.94 (0.60-1.48) | .800 |
| Lines of previous Tx | 1.85 (1.17-2.95) | .009 | 1.65 (1.10-2.48) | .015 | 2.73 (1.33-5.60) | .006 | 1.80 (0.97-3.34) | .064 | 1.32 (0.79-2.22) | .289 |