Patient demographic and disease characteristics
| Characteristic . | Value* . |
|---|---|
| Total, eligible patients | 367 |
| Protocol/treatment regimen | |
| 00-001 Pediatric early | 35 (10) |
| 05-001 (n = 11 treated as per) Pediatric late | 82 (22) |
| 01-175 Adult early | 92 (25) |
| 06-254 (n = 48 treated as per) Adult late | 158 (43) |
| Age, median (range), years | 23 (15, 50) |
| 15-19 | 138 (38) |
| 20-29 | 110 (30) |
| 30-39 | 62 (17) |
| 40-50 | 57 (16) |
| WBC, median (range), ×103/μL | 12.2 (0.1, 708.8) |
| <30 | 249 (68) |
| ≥30 | 117 (32) |
| Unknown | 1 (<1) |
| Blast %, median (range) | 23 (0, 98) |
| Sex | |
| Female | 142 (39) |
| Male | 225 (61) |
| Immunophenotype† | |
| B cell | 281 (77) |
| T cell | 86 (23) |
| CNS status | |
| CNS 1 | 281 (77) |
| CNS 2 | 38 (10) |
| CNS 3 | 11 (3) |
| Traumatic tap with blasts | 7 (2) |
| Traumatic tap without blasts | 18 (5) |
| Not performed | 12 (3) |
| Mediastinal mass | |
| Yes | 62 (17) |
| No | 299 (82) |
| Not evaluated | 6 (1) |
| Philadelphia chromosome positive | 44 (12) |
| KMT2A rearrangement (n = 330) | 20 (6) |
| High hyperdiploid (51-67 chromosomes) (n = 325) | 42 (13) |
| Complex karyotype ≥3 abnormalities (n = 228) | 45 (20) |
| BMI at diagnosis, median (range), kg/m2‡ | 24.5 (13.9, 57.0) |
| Underweight, <18.5 | 16 (4) |
| Normal, 18.5-24.9 | 182 (50) |
| Overweight, 25-29.9 | 94 (26) |
| Obese, 30-39.9 | 59 (16) |
| Morbidly obese, ≥40 | 16 (4) |
| Characteristic . | Value* . |
|---|---|
| Total, eligible patients | 367 |
| Protocol/treatment regimen | |
| 00-001 Pediatric early | 35 (10) |
| 05-001 (n = 11 treated as per) Pediatric late | 82 (22) |
| 01-175 Adult early | 92 (25) |
| 06-254 (n = 48 treated as per) Adult late | 158 (43) |
| Age, median (range), years | 23 (15, 50) |
| 15-19 | 138 (38) |
| 20-29 | 110 (30) |
| 30-39 | 62 (17) |
| 40-50 | 57 (16) |
| WBC, median (range), ×103/μL | 12.2 (0.1, 708.8) |
| <30 | 249 (68) |
| ≥30 | 117 (32) |
| Unknown | 1 (<1) |
| Blast %, median (range) | 23 (0, 98) |
| Sex | |
| Female | 142 (39) |
| Male | 225 (61) |
| Immunophenotype† | |
| B cell | 281 (77) |
| T cell | 86 (23) |
| CNS status | |
| CNS 1 | 281 (77) |
| CNS 2 | 38 (10) |
| CNS 3 | 11 (3) |
| Traumatic tap with blasts | 7 (2) |
| Traumatic tap without blasts | 18 (5) |
| Not performed | 12 (3) |
| Mediastinal mass | |
| Yes | 62 (17) |
| No | 299 (82) |
| Not evaluated | 6 (1) |
| Philadelphia chromosome positive | 44 (12) |
| KMT2A rearrangement (n = 330) | 20 (6) |
| High hyperdiploid (51-67 chromosomes) (n = 325) | 42 (13) |
| Complex karyotype ≥3 abnormalities (n = 228) | 45 (20) |
| BMI at diagnosis, median (range), kg/m2‡ | 24.5 (13.9, 57.0) |
| Underweight, <18.5 | 16 (4) |
| Normal, 18.5-24.9 | 182 (50) |
| Overweight, 25-29.9 | 94 (26) |
| Obese, 30-39.9 | 59 (16) |
| Morbidly obese, ≥40 | 16 (4) |