Table 2.

Cumulative incidence of ON and fracture

Variable5-y Cumulative Incidence: ON, % [95% CI]P*5-y Cumulative Incidence: Fracture, % [95% CI]P*
Overall 17 [13-22]  12 [8-15]  
Treatment regimens     
 Early generation 5 [2-10] <.001 9 [5-16] .74 
 Late generation 24 [18-30]  13 [9-18]  
Age     
 <20 y 18 [12-25] .003 14 [9-21] .44 
 20-29 y 26 [17-36]  10 [5-18]  
 30-39 y 12 [5-23]  14 [6-26]  
 ≥40 y 4 [1-11]  7 [2-17]  
Age     
 <30 y 21 [16-27] .004 12 [8-17] .54 
 ≥30 y 8 [4-14]  11 [6-18]  
BMI at diagnosis, kg/m2     
 Underweight/normal 19 [14-26] .53 14 [9-20] .39 
 Overweight 14 [8-23]  9 [4-16]  
 Morbidly obese/obese 15 [8-26]  10 [4-18]  
Sex     
 Male 16 [11-22] .50 9 [6-13] .051 
 Female 19 [13-27]  17 [10-24]  
Lipidemia (grade 4) (N = 332)†     
 Yes 32 [18-46] .019 5 [1-16] .11 
 No 16 [12-21]  13 [9-17]  
Variable5-y Cumulative Incidence: ON, % [95% CI]P*5-y Cumulative Incidence: Fracture, % [95% CI]P*
Overall 17 [13-22]  12 [8-15]  
Treatment regimens     
 Early generation 5 [2-10] <.001 9 [5-16] .74 
 Late generation 24 [18-30]  13 [9-18]  
Age     
 <20 y 18 [12-25] .003 14 [9-21] .44 
 20-29 y 26 [17-36]  10 [5-18]  
 30-39 y 12 [5-23]  14 [6-26]  
 ≥40 y 4 [1-11]  7 [2-17]  
Age     
 <30 y 21 [16-27] .004 12 [8-17] .54 
 ≥30 y 8 [4-14]  11 [6-18]  
BMI at diagnosis, kg/m2     
 Underweight/normal 19 [14-26] .53 14 [9-20] .39 
 Overweight 14 [8-23]  9 [4-16]  
 Morbidly obese/obese 15 [8-26]  10 [4-18]  
Sex     
 Male 16 [11-22] .50 9 [6-13] .051 
 Female 19 [13-27]  17 [10-24]  
Lipidemia (grade 4) (N = 332)†     
 Yes 32 [18-46] .019 5 [1-16] .11 
 No 16 [12-21]  13 [9-17]  
*

The Gray test.

†

Excludes 00-001 protocol. Includes hypertriglyceridemia and hypercholesterolemia. No grade 5 events were observed.

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