Table 4.

Univariate and multivariable Cox modeling for OS

VariableOS Univariate, HR [95% CI]POS Multivariable, HR [95% CI]P
ON* 0.11 [0.04-0.35] .0002 0.15 [0.05-0.46] .001 
 Age 30-50 y vs < 30 y 1.88 [1.27-2.78] .002 1.42 [0.93-2.16] .11 
 Sex, male vs female 1.08 [0.72-1.61] .72   
 WBC , ≥50 x103/μL vs <50 2.10 [1.42-3.10] .0002 2.17 [1.45-3.23] .0002 
 B cell vs T cell 2.31 [1.29-4.14] .005 2.31 [1.27-4.18] .006 
 CNS blasts vs no blasts 1.41 [0.84-2.35] .19   
 CNS Unknown vs no blasts 0.89 [0.45-1.79] .75   
 Philadelphia chromosome positive, yes vs no 1.89 [1.12-3.19] .017 1.03 [0.59-1.79] .92 
 Philadelphia chromosome Unknown vs no 1.81 [0.25-12.98] .56 2.25 [0.30-17.01] .43 
 BMI     
  Morbidly obese/obese vs underweight/normal 2.25 [1.39-3.64] .001 1.91 [1.16-3.15] .011 
  Overweight vs underweight/normal 2.27 [1.43-3.59] .0005 2.19 [1.36-3.53] .001 
  Treatment regimen, late vs early 0.69 [0.47-1.02] .065   
Fracture* 0.31 [0.13-0.77] .012 0.40 [0.16-0.99] .048 
 Age 30-50 vs <30 y 1.88 [1.27-2.78] .002 1.62 [1.06-2.48] .026 
 Sex male vs female 1.08 [0.72-1.61] .72   
 WBC ≥50 x103/μL vs <50 2.10 [1.42-3.10] .0002 2.30 [1.54-3.44] <.001 
 B cell vs T cell 2.31 [1.29-4.14] .005 2.31 [1.27-4.18] .006 
 CNS blasts vs no blasts 1.41 [0.84-2.35] .19   
 CNS Unknown vs no blasts 0.89 [0.45-1.79] .75   
 Philadelphia chromosome positive, yes vs no 1.89 [1.12-3.19] .017 1.06 [0.61-1.85] .84 
 Philadelphia chromosome unknown vs no 1.81 [0.25-12.98] .56 1.68 [0.22-12.70] .61 
 BMI     
  Morbidly obese/obese vs underweight/normal 2.25 [1.39-3.64] .001 1.89 [1.14-3.13] .013 
  Overweight vs underweight/normal 2.27 [1.43-3.59] .0005 2.31 [1.27-4.18] .006 
  Treatment regimen, late vs early 0.69 [0.47-1.02] .065   
VariableOS Univariate, HR [95% CI]POS Multivariable, HR [95% CI]P
ON* 0.11 [0.04-0.35] .0002 0.15 [0.05-0.46] .001 
 Age 30-50 y vs < 30 y 1.88 [1.27-2.78] .002 1.42 [0.93-2.16] .11 
 Sex, male vs female 1.08 [0.72-1.61] .72   
 WBC , ≥50 x103/μL vs <50 2.10 [1.42-3.10] .0002 2.17 [1.45-3.23] .0002 
 B cell vs T cell 2.31 [1.29-4.14] .005 2.31 [1.27-4.18] .006 
 CNS blasts vs no blasts 1.41 [0.84-2.35] .19   
 CNS Unknown vs no blasts 0.89 [0.45-1.79] .75   
 Philadelphia chromosome positive, yes vs no 1.89 [1.12-3.19] .017 1.03 [0.59-1.79] .92 
 Philadelphia chromosome Unknown vs no 1.81 [0.25-12.98] .56 2.25 [0.30-17.01] .43 
 BMI     
  Morbidly obese/obese vs underweight/normal 2.25 [1.39-3.64] .001 1.91 [1.16-3.15] .011 
  Overweight vs underweight/normal 2.27 [1.43-3.59] .0005 2.19 [1.36-3.53] .001 
  Treatment regimen, late vs early 0.69 [0.47-1.02] .065   
Fracture* 0.31 [0.13-0.77] .012 0.40 [0.16-0.99] .048 
 Age 30-50 vs <30 y 1.88 [1.27-2.78] .002 1.62 [1.06-2.48] .026 
 Sex male vs female 1.08 [0.72-1.61] .72   
 WBC ≥50 x103/μL vs <50 2.10 [1.42-3.10] .0002 2.30 [1.54-3.44] <.001 
 B cell vs T cell 2.31 [1.29-4.14] .005 2.31 [1.27-4.18] .006 
 CNS blasts vs no blasts 1.41 [0.84-2.35] .19   
 CNS Unknown vs no blasts 0.89 [0.45-1.79] .75   
 Philadelphia chromosome positive, yes vs no 1.89 [1.12-3.19] .017 1.06 [0.61-1.85] .84 
 Philadelphia chromosome unknown vs no 1.81 [0.25-12.98] .56 1.68 [0.22-12.70] .61 
 BMI     
  Morbidly obese/obese vs underweight/normal 2.25 [1.39-3.64] .001 1.89 [1.14-3.13] .013 
  Overweight vs underweight/normal 2.27 [1.43-3.59] .0005 2.31 [1.27-4.18] .006 
  Treatment regimen, late vs early 0.69 [0.47-1.02] .065   

CNS, central nervous system; WBC, white blood cell.

*

Included as a time-varying covariate.

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