Summary of findings of studies in which clinicians prescribed TXA only for patients with VWD undergoing minor surgery
| Outcome . | No. of participants . | No. of observational studies . | Certainty of evidence . | GRADE . | Impact . |
|---|---|---|---|---|---|
| Several definitions for bleeding; No. of events and total No. of patients or surgeries | 119 | 4 | ⨁◯◯◯ | Very low* | Pooled analysis showed that the proportion of patients or surgeries with bleeding was 14% (95% CI, 9%-20%). |
| Hospitalization days per surgery | 22 | 1 | ⨁◯◯◯ | Very low* | Mean, 4 (no 95% CI provided). |
| Outcome . | No. of participants . | No. of observational studies . | Certainty of evidence . | GRADE . | Impact . |
|---|---|---|---|---|---|
| Several definitions for bleeding; No. of events and total No. of patients or surgeries | 119 | 4 | ⨁◯◯◯ | Very low* | Pooled analysis showed that the proportion of patients or surgeries with bleeding was 14% (95% CI, 9%-20%). |
| Hospitalization days per surgery | 22 | 1 | ⨁◯◯◯ | Very low* | Mean, 4 (no 95% CI provided). |
The following outcomes were not reported in the studies: Need for additional hemostatic agents, need for additional surgical procedures, serious AEs, mortality, transfusion, inability to perform the surgery. GRADE Working Group grades of evidence: Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.
The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).