Table 1. Unique exon 1 sequences in... | American Society of Hematology

Table 1.

Unique exon 1 sequences in cohort 1

Deduced leader peptide	Nucleotide sequence for nonamer peptide									Total (% of total cohort)
Deduced leader peptide	P1	P2	P3	P4	P5	P6	P7	P8	P9	Total (% of total cohort)
VMAPRTVLL*	GTC	ATG	GCG	CCC	CGA	ACC	GTC	CTC	CTG	683 153 (31.1)
VTAPRTVLL†	—	-C-	—	—	—	—	—	—	—	670 904 (30.5)
VTAPRTLLL‡	—	-C-	—	—	—	—	C-	—	—	542 311 (24.7)
VTAPRTVLL†	—	-C-	-A	—	—	—	—	—	—	242 366 (11.0)
VTAPRTLLL‡	—	-C-	-A	—	—	—	C-	—	—	57 747 (2.6)
VTEPRTLLL	—	-C-	-A-	—	—	—	C-	—	—	107
VMAPRTVLL*	—	—	—	—	A-	—	—	—	—	25
VMAPRTVLL*	—	—	-A	—	—	—	—	—	—	21
VTAPRTVLL†	—	-CC	—	—	—	—	—	—	—	16
VTAPRTLLL‡	—	-C-	-T	—	—	—	C-	—	—	10
VTAPRTLFL	—	-C-	-A	—	—	—	C-	T-	—	7
VTASRTLLL	—	-C-	—	T-	—	—	C-	—	—	6
VMAPRTLLL	—	—	—	—	—	—	C-	—	—	5
VTASRTVLL	—	-C-	—	T-	—	—	—	—	—	4
VRAPRTLLL	—	-G-	-A	—	—	—	C-	—	—	3
VTAPRTILL	—	-C-	—	—	—	—	A-	—	—	3
VTAPRNLLL	—	-C-	—	—	—	-A-	C-–	—	—	3
VMAPRTVLL*	—	—	—	—	—	—	—	—	T-	3
VTAPRTVLL†	—	-C-	-A	—	—	—	—	—	-A	3
VTAPQTVLL	—	-C-	—	—	-A-	—	—	—	—	3
VTATRTLLL	—	-C-	—	A-	—	—	C-	—	—	2
VTALRTVLL	—	-C-	—	-T-	—	—	—	—	—	1
VTAPRTLVL	—	-C-	—	—	—	—	C-	G-	—	1
ITAPRTVLL	A-	-C-	—	—	—	—	—	—	—	1
VMEPRTVLL	—	—	-A-	—	—	—	—	—	—	1
VTAP*TLLL	—	-C-	—	—	T-	—	C-	—	—	1
VTAPRTLLL‡	—	-C-	—	—	—	—	C-	—	-A	1
VTAPRTFLL	—	-C-	—	—	—	—	T–	—	—	1
VMATRTVLL	—	—	—	A-	—	—	—	—	—	1
VMAPGTVLL	—	—	—	—	G-	—	—	—	—	1
VTAPRTVLQ	—	-C-	—	—	—	—	—	—	-A-	1
VMAPRSVLL	—	—	—	—	—	-G-	—	—	—	1
VVAPRTVLL	—	G-	—	—	—	—	—	—	—	1
VMVPRTVLL	—	—	-T-	—	—	—	—	—	—	1
VMAPRTVLV	—	—	—	—	—	—	—	—	G-	1
Total										2 196 716

Deduced leader peptide	Nucleotide sequence for nonamer peptide									Total (% of total cohort)
Deduced leader peptide	P1	P2	P3	P4	P5	P6	P7	P8	P9	Total (% of total cohort)
VMAPRTVLL*	GTC	ATG	GCG	CCC	CGA	ACC	GTC	CTC	CTG	683 153 (31.1)
VTAPRTVLL†	—	-C-	—	—	—	—	—	—	—	670 904 (30.5)
VTAPRTLLL‡	—	-C-	—	—	—	—	C-	—	—	542 311 (24.7)
VTAPRTVLL†	—	-C-	-A	—	—	—	—	—	—	242 366 (11.0)
VTAPRTLLL‡	—	-C-	-A	—	—	—	C-	—	—	57 747 (2.6)
VTEPRTLLL	—	-C-	-A-	—	—	—	C-	—	—	107
VMAPRTVLL*	—	—	—	—	A-	—	—	—	—	25
VMAPRTVLL*	—	—	-A	—	—	—	—	—	—	21
VTAPRTVLL†	—	-CC	—	—	—	—	—	—	—	16
VTAPRTLLL‡	—	-C-	-T	—	—	—	C-	—	—	10
VTAPRTLFL	—	-C-	-A	—	—	—	C-	T-	—	7
VTASRTLLL	—	-C-	—	T-	—	—	C-	—	—	6
VMAPRTLLL	—	—	—	—	—	—	C-	—	—	5
VTASRTVLL	—	-C-	—	T-	—	—	—	—	—	4
VRAPRTLLL	—	-G-	-A	—	—	—	C-	—	—	3
VTAPRTILL	—	-C-	—	—	—	—	A-	—	—	3
VTAPRNLLL	—	-C-	—	—	—	-A-	C-–	—	—	3
VMAPRTVLL*	—	—	—	—	—	—	—	—	T-	3
VTAPRTVLL†	—	-C-	-A	—	—	—	—	—	-A	3
VTAPQTVLL	—	-C-	—	—	-A-	—	—	—	—	3
VTATRTLLL	—	-C-	—	A-	—	—	C-	—	—	2
VTALRTVLL	—	-C-	—	-T-	—	—	—	—	—	1
VTAPRTLVL	—	-C-	—	—	—	—	C-	G-	—	1
ITAPRTVLL	A-	-C-	—	—	—	—	—	—	—	1
VMEPRTVLL	—	—	-A-	—	—	—	—	—	—	1
VTAP*TLLL	—	-C-	—	—	T-	—	C-	—	—	1
VTAPRTLLL‡	—	-C-	—	—	—	—	C-	—	-A	1
VTAPRTFLL	—	-C-	—	—	—	—	T–	—	—	1
VMATRTVLL	—	—	—	A-	—	—	—	—	—	1
VMAPGTVLL	—	—	—	—	G-	—	—	—	—	1
VTAPRTVLQ	—	-C-	—	—	—	—	—	—	-A-	1
VMAPRSVLL	—	—	—	—	—	-G-	—	—	—	1
VVAPRTVLL	—	G-	—	—	—	—	—	—	—	1
VMVPRTVLL	—	—	-T-	—	—	—	—	—	—	1
VMAPRTVLV	—	—	—	—	—	—	—	—	G-	1
Total										2 196 716

The 1 098 358 donors in cohort 1 contain 2 196 716 observed exon 1 nucleotide sequences (each of which encodes a deduced peptide sequence). Each row details a unique nucleotide sequence. Nucleotide sequence rows are sorted by decreasing observations. Nucleotide sequences are aligned with the most frequent sequence; hyphens indicate consensus nucleotides. The asterisk within VTAP*TLLL indicates a deduced stop codon. The P2 sequence is indicated in bold, which is deduced to encode thymine (T) (1 513 499 observations); methionine (M) (683 213 observations); arginine (R) (three observations), or valine (V) (one observation). Percentages are provided for the top 5 peptides, which represent 99.99% of all observations. Race information for each peptide is provided in Table 4. Deduced leader peptides with multiple unique nucleotide sequences are annotated with footnotes.

*,†,‡

These deduced leader peptides have 4 unique exon 1 sequences each in cohort 1.

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