HLA-B leader genotype and allele frequencies in 5 US continental races in the base cohort
| Donor race categories . | No. of donors . | Leader allele frequencies (%) . | Leader genotype frequencies (%) . | |||
|---|---|---|---|---|---|---|
| T . | M . | TT . | MT . | MM . | ||
| White | 5 224 777 | 67.8 | 32.2 | 46.2 | 43.3 | 10.5 |
| Hispanic or Latino | 1 289 395 | 72.7 | 27.3 | 53.0 | 39.3 | 7.7 |
| Asian or Pacific Islander | 951 723 | 85.6 | 14.4 | 73.6 | 24.0 | 2.4 |
| Black or African American | 837 531 | 75.4 | 24.6 | 56.9 | 36.9 | 6.1 |
| American Indian or Alaskan Native | 79 858 | 71.1 | 28.9 | 51.0 | 40.1 | 8.8 |
| Donor race categories . | No. of donors . | Leader allele frequencies (%) . | Leader genotype frequencies (%) . | |||
|---|---|---|---|---|---|---|
| T . | M . | TT . | MT . | MM . | ||
| White | 5 224 777 | 67.8 | 32.2 | 46.2 | 43.3 | 10.5 |
| Hispanic or Latino | 1 289 395 | 72.7 | 27.3 | 53.0 | 39.3 | 7.7 |
| Asian or Pacific Islander | 951 723 | 85.6 | 14.4 | 73.6 | 24.0 | 2.4 |
| Black or African American | 837 531 | 75.4 | 24.6 | 56.9 | 36.9 | 6.1 |
| American Indian or Alaskan Native | 79 858 | 71.1 | 28.9 | 51.0 | 40.1 | 8.8 |
Allele frequencies across populations vary for T (67.8%-85.6%) and M (14.4%-32.2%), and genotype frequencies vary for TT (51.0%-73.6%), MT (24.0%-43.3%), and MM (2.4%-10.5%). Genotype frequencies were found to differ significantly across races using Pearson's χ2 test of independence (8, N = 9 417 614) = 273 178, P < 2.2 × 10-16. The base cohort total is 9 417 614. There are 1 034 330 omitted donors with a race that is unknown, multirace, other, or was declined to be reported.