Multivariable Cox proportional hazard regression (n = 429)
| . | n=429, 87 events . | . | . | ||
|---|---|---|---|---|---|
| Covariate . | HR (95%) . | P-value . | z-Wald . | (Ratio) weight . | |
| Age 65+ y | 3.51 (2.20-5.60) | <.001 | 5.27 | (1.8) 2 | |
| Gender M | 2.04 (1.27-3.27) | .003 | 2.96 | (1.0) 1 | |
| ALC ≤650 | 2.14 (1.37-3.34) | .001 | 3.35 | (1.2) 1 | |
| Platelets <100 | 2.14 (1.37-3.34) | .001 | 2.89 | 1.00 | |
| C-Harrell | 0.725 (0.673-0.777) | ||||
| Internal validation | |||||
| C-index Harrell (95% CI) | Reference: 0.725 (0.673-0.777). Bias corrected: 0.716 (optimism 0.018) | ||||
| Slope shrinkage | Optimism: 0.057, slope: 0.943 | ||||
| . | n=429, 87 events . | . | . | ||
|---|---|---|---|---|---|
| Covariate . | HR (95%) . | P-value . | z-Wald . | (Ratio) weight . | |
| Age 65+ y | 3.51 (2.20-5.60) | <.001 | 5.27 | (1.8) 2 | |
| Gender M | 2.04 (1.27-3.27) | .003 | 2.96 | (1.0) 1 | |
| ALC ≤650 | 2.14 (1.37-3.34) | .001 | 3.35 | (1.2) 1 | |
| Platelets <100 | 2.14 (1.37-3.34) | .001 | 2.89 | 1.00 | |
| C-Harrell | 0.725 (0.673-0.777) | ||||
| Internal validation | |||||
| C-index Harrell (95% CI) | Reference: 0.725 (0.673-0.777). Bias corrected: 0.716 (optimism 0.018) | ||||
| Slope shrinkage | Optimism: 0.057, slope: 0.943 | ||||
Internal validation performed after 1000 bootstrap resamples. N = 429 complete cases for age, sex, Hb, ALC, platelets, istology, patient status at CODIV-19 diagnosis, Charlson index, smoker, treatment yes/no, and time lapse from lymphoma to COVID-19.
Ratio, ratio between the z-score for any factor divided by minimum z-score observed (platelets, considered as reference). The weights were obtained rounding the ratio. Score, sum of weights.