Multivariable logistic regression of predictors of inpatient death and discharge to hospice among 1464 adult patients with APL
| Variable . | OR . | 95% CI . | P . | Predicted margin . |
|---|---|---|---|---|
| Age, y | ||||
| ≤39 y | 1.00 | 0.047 | ||
| 40-59 y | 2.68 | 1.52-4.71 | .001 | 0.110 |
| ≥60 y | 7.59 | 4.39-13.13 | <.001 | 0.237 |
| Sex | ||||
| Male | 1.00 | 0.146 | ||
| Female | 0.89 | 0.64-1.23 | .46 | 0.134 |
| Race | ||||
| White | 1.00 | 0.140 | ||
| African American | 0.57 | 0.31-1.03 | .06 | 0.091 |
| Unknown/Other | 1.40 | 0.88-2.25 | .16 | 0.178 |
| Ethnicity | ||||
| Non-Hispanic | 1.00 | 0.131 | ||
| Hispanic | 0.77 | 0.40-1.48 | .43 | 0.107 |
| Unknown | 2.20 | 1.35-3.60 | .002 | 0.225 |
| Hospital region | ||||
| West | 1.00 | 0.170 | ||
| Midwest | 0.65 | 0.37-1.15 | .14 | 0.125 |
| South | 0.89 | 0.54-1.50 | .66 | 0.158 |
| Northeast | 0.50 | 0.27-0.92 | .03 | 0.103 |
| Hospital AML patient volume per year | ||||
| ≤50 | 1.00 | 0.211 | ||
| 51-100 | 0.52 | 0.32-0.89 | .02 | 0.134 |
| 101-200 | 0.55 | 0.34-0.87 | .01 | 0.139 |
| >200 | 0.35 | 0.19-0.63 | <.001 | 0.100 |
| Risk status | ||||
| Low risk (WBC ≤10 G/L) | 1.00 | 0.068 | ||
| High risk (WBC >10 G/L) | 4.27 | 2.86-6.39 | <.001 | 0.209 |
| Unknown | 5.20 | 1.70-15.94 | .004 | 0.238 |
| Platelet count on admission | ||||
| <50 G/L | 1.00 | 0.166 | ||
| 50-150 G/L | 0.76 | 0.47-1.23 | .26 | 0.137 |
| >150 G/L | 0.34 | 0.07-1.60 | .17 | 0.073 |
| Unknown | 0.54 | 0.18-1.62 | .27 | 0.106 |
| Time to treatment initiation | ||||
| ≤2 d after admission | 1.00 | 0.139 | ||
| >2 d after admission | 1.12 | 0.56-2.25 | .75 | 0.151 |
| Coagulopathy | ||||
| Yes | 1.00 | 0.186 | ||
| No | 0.56 | 0.35-0.89 | .01 | 0.123 |
| Unknown | 0.46 | 0.26-0.82 | .008 | 0.105 |
| Variable . | OR . | 95% CI . | P . | Predicted margin . |
|---|---|---|---|---|
| Age, y | ||||
| ≤39 y | 1.00 | 0.047 | ||
| 40-59 y | 2.68 | 1.52-4.71 | .001 | 0.110 |
| ≥60 y | 7.59 | 4.39-13.13 | <.001 | 0.237 |
| Sex | ||||
| Male | 1.00 | 0.146 | ||
| Female | 0.89 | 0.64-1.23 | .46 | 0.134 |
| Race | ||||
| White | 1.00 | 0.140 | ||
| African American | 0.57 | 0.31-1.03 | .06 | 0.091 |
| Unknown/Other | 1.40 | 0.88-2.25 | .16 | 0.178 |
| Ethnicity | ||||
| Non-Hispanic | 1.00 | 0.131 | ||
| Hispanic | 0.77 | 0.40-1.48 | .43 | 0.107 |
| Unknown | 2.20 | 1.35-3.60 | .002 | 0.225 |
| Hospital region | ||||
| West | 1.00 | 0.170 | ||
| Midwest | 0.65 | 0.37-1.15 | .14 | 0.125 |
| South | 0.89 | 0.54-1.50 | .66 | 0.158 |
| Northeast | 0.50 | 0.27-0.92 | .03 | 0.103 |
| Hospital AML patient volume per year | ||||
| ≤50 | 1.00 | 0.211 | ||
| 51-100 | 0.52 | 0.32-0.89 | .02 | 0.134 |
| 101-200 | 0.55 | 0.34-0.87 | .01 | 0.139 |
| >200 | 0.35 | 0.19-0.63 | <.001 | 0.100 |
| Risk status | ||||
| Low risk (WBC ≤10 G/L) | 1.00 | 0.068 | ||
| High risk (WBC >10 G/L) | 4.27 | 2.86-6.39 | <.001 | 0.209 |
| Unknown | 5.20 | 1.70-15.94 | .004 | 0.238 |
| Platelet count on admission | ||||
| <50 G/L | 1.00 | 0.166 | ||
| 50-150 G/L | 0.76 | 0.47-1.23 | .26 | 0.137 |
| >150 G/L | 0.34 | 0.07-1.60 | .17 | 0.073 |
| Unknown | 0.54 | 0.18-1.62 | .27 | 0.106 |
| Time to treatment initiation | ||||
| ≤2 d after admission | 1.00 | 0.139 | ||
| >2 d after admission | 1.12 | 0.56-2.25 | .75 | 0.151 |
| Coagulopathy | ||||
| Yes | 1.00 | 0.186 | ||
| No | 0.56 | 0.35-0.89 | .01 | 0.123 |
| Unknown | 0.46 | 0.26-0.82 | .008 | 0.105 |
Predictive margins were calculated for each variable from a previously fitted multivariable regression model and describe the average probability for a patient in a given category to experience the adverse outcome with the other variables kept constant. Data from the Vizient CDB used with permission of Vizient, Inc. All rights reserved.