Multivariable logistic regression of predictors of inpatient death and discharge to hospice among 1,008 APL patients with LOS >3 days and known risk status
| Variable . | OR . | 95% CI . | P . | Predicted margin . |
|---|---|---|---|---|
| Age | ||||
| ≤39 y | 1.00 | 0.023 | ||
| 40-59 y | 4.34 | 1.76-10.74 | .001 | 0.087 |
| ≥60 y | 11.1 | 4.55-27.23 | <.001 | 0.182 |
| Sex | ||||
| Male | 1.00 | 0.113 | ||
| Female | 0.77 | 0.49-1.21 | .26 | 0.093 |
| Race | ||||
| White | 1.00 | 0.099 | ||
| African American | 0.78 | 0.36-1.65 | .51 | 0.081 |
| Unknown/other | 1.68 | 0.86-3.29 | .13 | 0.146 |
| Ethnicity | ||||
| Non-Hispanic | 1.00 | 0.101 | ||
| Hispanic | 0.98 | 0.38-2.46 | .95 | 0.098 |
| Unknown | 1.33 | 0.61-2.87 | .48 | 0.125 |
| Hospital region | ||||
| West | 1.00 | 0.106 | ||
| Midwest | 0.83 | 0.38-1.83 | .65 | 0.092 |
| South | 1.12 | 0.56-2.27 | .75 | 0.115 |
| Northeast | 0.77 | 0.31-1.90 | .57 | 0.086 |
| Hospital AML patient volume per year | ||||
| ≤50 | 1.00 | 0.159 | ||
| 51-100 | 0.43 | 0.20-0.92 | .03 | 0.085 |
| 101-200 | 0.54 | 0.29-1.02 | .06 | 0.100 |
| >200 | 0.44 | 0.20-0.99 | .046 | 0.085 |
| Risk status | ||||
| Low risk (WBC ≤10 G/L) | 1.00 | 0.074 | ||
| High risk (WBC >10 G/L) | 2.48 | 1.53-4.00 | <.001 | 0.152 |
| Platelet count on admission | ||||
| <50 G/L | 1.00 | 0.109 | ||
| 50-150 G/L | 0.78 | 0.45-1.37 | .39 | 0.090 |
| >150 G/L | 0.30 | 0.04-2.47 | .26 | 0.040 |
| Unknown | Omitted | |||
| Time to treatment initiation | ||||
| ≤2 d after admission | 1.00 | 0.099 | ||
| >2 d after admission | 1.98 | 0.82-4.76 | .13 | 0.164 |
| Coagulopathy | ||||
| Yes | 1.00 | 0.124 | ||
| No | 0.67 | 0.39-1.13 | .13 | 0.090 |
| Unknown | 0.37 | 0.17-0.82 | .02 | 0.056 |
| NCCN guideline–concordant treatment | ||||
| Yes | 1.00 | 0.083 | ||
| No | 2.31 | 1.43-3.75 | .001 | 0.160 |
| Variable . | OR . | 95% CI . | P . | Predicted margin . |
|---|---|---|---|---|
| Age | ||||
| ≤39 y | 1.00 | 0.023 | ||
| 40-59 y | 4.34 | 1.76-10.74 | .001 | 0.087 |
| ≥60 y | 11.1 | 4.55-27.23 | <.001 | 0.182 |
| Sex | ||||
| Male | 1.00 | 0.113 | ||
| Female | 0.77 | 0.49-1.21 | .26 | 0.093 |
| Race | ||||
| White | 1.00 | 0.099 | ||
| African American | 0.78 | 0.36-1.65 | .51 | 0.081 |
| Unknown/other | 1.68 | 0.86-3.29 | .13 | 0.146 |
| Ethnicity | ||||
| Non-Hispanic | 1.00 | 0.101 | ||
| Hispanic | 0.98 | 0.38-2.46 | .95 | 0.098 |
| Unknown | 1.33 | 0.61-2.87 | .48 | 0.125 |
| Hospital region | ||||
| West | 1.00 | 0.106 | ||
| Midwest | 0.83 | 0.38-1.83 | .65 | 0.092 |
| South | 1.12 | 0.56-2.27 | .75 | 0.115 |
| Northeast | 0.77 | 0.31-1.90 | .57 | 0.086 |
| Hospital AML patient volume per year | ||||
| ≤50 | 1.00 | 0.159 | ||
| 51-100 | 0.43 | 0.20-0.92 | .03 | 0.085 |
| 101-200 | 0.54 | 0.29-1.02 | .06 | 0.100 |
| >200 | 0.44 | 0.20-0.99 | .046 | 0.085 |
| Risk status | ||||
| Low risk (WBC ≤10 G/L) | 1.00 | 0.074 | ||
| High risk (WBC >10 G/L) | 2.48 | 1.53-4.00 | <.001 | 0.152 |
| Platelet count on admission | ||||
| <50 G/L | 1.00 | 0.109 | ||
| 50-150 G/L | 0.78 | 0.45-1.37 | .39 | 0.090 |
| >150 G/L | 0.30 | 0.04-2.47 | .26 | 0.040 |
| Unknown | Omitted | |||
| Time to treatment initiation | ||||
| ≤2 d after admission | 1.00 | 0.099 | ||
| >2 d after admission | 1.98 | 0.82-4.76 | .13 | 0.164 |
| Coagulopathy | ||||
| Yes | 1.00 | 0.124 | ||
| No | 0.67 | 0.39-1.13 | .13 | 0.090 |
| Unknown | 0.37 | 0.17-0.82 | .02 | 0.056 |
| NCCN guideline–concordant treatment | ||||
| Yes | 1.00 | 0.083 | ||
| No | 2.31 | 1.43-3.75 | .001 | 0.160 |
Predictive margins were calculated for each variable from a previously fitted multivariable regression model and describe the average probability for a patient in a given category to experience the adverse outcome with the other variables kept constant. Data from the Vizient CDB used with permission of Vizient, Inc. All rights reserved.