Gene burden analysis results for genes achieving exome-wide significance
| Gene . | Gene name . | cMAF affected . | Cases, n . | cMAF unaffected . | Controls, n . | P . |
|---|---|---|---|---|---|---|
| CFB | Complement factor B | 0.023 | 4 | 0.000 | 0 | 3.03 × 10−8 |
| DNASE2 | Deoxyribonuclease 2, lysosomal | 0.041 | 7 | 0.004 | 5 | 3.53 × 10−7 |
| FGFRL1 | Fibroblast growth factor receptor-like 1 | 0.041 | 7 | 0.004 | 5 | 3.53 × 10−7 |
| NEURL3 | Neuralized E3 ubiquitin protein ligase 3 | 0.116 | 20 | 0.034 | 45 | 7.05 × 10−7 |
| CCL5 | C-C motif chemokine ligand 5 | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| IL5RA | Interleukin 5 receptor subunit α | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| KCNK18 | Potassium 2 pore domain channel subfamily k member 18 | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| TBCCD1 | TBCC domain containing 1 | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| TBL1X | Transducin β like 1X-linked | 0.029 | 5 | 0.002 | 3 | 6.11 × 10−6 |
| VWF | von Willebrand factor | 0.111 | 19 | 0.036 | 47 | 7.31 × 10−6 |
| Gene . | Gene name . | cMAF affected . | Cases, n . | cMAF unaffected . | Controls, n . | P . |
|---|---|---|---|---|---|---|
| CFB | Complement factor B | 0.023 | 4 | 0.000 | 0 | 3.03 × 10−8 |
| DNASE2 | Deoxyribonuclease 2, lysosomal | 0.041 | 7 | 0.004 | 5 | 3.53 × 10−7 |
| FGFRL1 | Fibroblast growth factor receptor-like 1 | 0.041 | 7 | 0.004 | 5 | 3.53 × 10−7 |
| NEURL3 | Neuralized E3 ubiquitin protein ligase 3 | 0.116 | 20 | 0.034 | 45 | 7.05 × 10−7 |
| CCL5 | C-C motif chemokine ligand 5 | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| IL5RA | Interleukin 5 receptor subunit α | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| KCNK18 | Potassium 2 pore domain channel subfamily k member 18 | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| TBCCD1 | TBCC domain containing 1 | 0.017 | 3 | 0.000 | 0 | 1.62 × 10−6 |
| TBL1X | Transducin β like 1X-linked | 0.029 | 5 | 0.002 | 3 | 6.11 × 10−6 |
| VWF | von Willebrand factor | 0.111 | 19 | 0.036 | 47 | 7.31 × 10−6 |