Summary of clinical and cytological data of del(11q) MDS and MDS/MPN compared with other MDS
| Characteristics . | del(11q) MDS and MDS/MPN . | del(11q) MDS . | Other MDS . | P value MDS . |
|---|---|---|---|---|
| Patients | 113 | 103 | 88 | |
| Age, years, median (range) | 74 (31-94) | 74 (31-94) | 71 (44-94) | 0.24 |
| Sex ratio | 0.74 | 0.74 | 1.26 | 0.020 |
| Blood count | ||||
| Hemoglobin (Hb), g/dL, median (range) | 9.9 (4.5-14.8) | 9.9 (5.5-14.8) | 9.4 (6.4-14.9) | 0.14 |
| Anemia (Hb <10 g/dL) | 52% | 52% | 58% | 0.43 |
| Mean corpuscular volume, fL, median (range) | 101 (77-139) | 101 (77-139) | 99.5 (76-129) | 0.035 |
| Platelets (plt), G/L, median (range) | 173 (17-1234) | 173 (17-1234) | 183 (5-494) | 0.71 |
| Thrombocytopenia (plt <100 G/L) | 32% | 32% | 27% | 0.44 |
| White blood count (WBC), G/L, median (range) | 4.0 (1.0-94) | 4.0 (1.0-18.4) | 4.2 (1.0-18.4) | 0.85 |
| Neutrophil Count (ANC), G/L median (range) | 2.3 (0.2-52.6) | 2.0 (0.2-13.4) | 2.2 (0.3-15.8) | 0.61 |
| Neutropenia (ANC <1.8 G/L) | 36% | 36% | 37% | 0.96 |
| Monocyte count, G/L, median (range) | 0.3 (0-15) | 0.2 (0-0.9) | 0.4 (0-0.9) | 0.0004 |
| Lymphocyte count, G/L, median (range) | 1.2 (0-5.0) | 1.1 (0.1-3.5) | 1.3 (0.3-3.7) | 0.57 |
| Bone marrow | ||||
| % BM blasts, median (range) | 4 (0-14) | 4 (0-13) | 3 (0-19) | 0.086 |
| Dyserythropoiesis | 73% | 75% | 71% | 0.58 |
| Dysgranulopoiesis | 51% | 51% | 69% | 0.025 |
| Dysmegakaryopoiesis | 78% | 80% | 57% | 0.001 |
| Characteristics . | del(11q) MDS and MDS/MPN . | del(11q) MDS . | Other MDS . | P value MDS . |
|---|---|---|---|---|
| Patients | 113 | 103 | 88 | |
| Age, years, median (range) | 74 (31-94) | 74 (31-94) | 71 (44-94) | 0.24 |
| Sex ratio | 0.74 | 0.74 | 1.26 | 0.020 |
| Blood count | ||||
| Hemoglobin (Hb), g/dL, median (range) | 9.9 (4.5-14.8) | 9.9 (5.5-14.8) | 9.4 (6.4-14.9) | 0.14 |
| Anemia (Hb <10 g/dL) | 52% | 52% | 58% | 0.43 |
| Mean corpuscular volume, fL, median (range) | 101 (77-139) | 101 (77-139) | 99.5 (76-129) | 0.035 |
| Platelets (plt), G/L, median (range) | 173 (17-1234) | 173 (17-1234) | 183 (5-494) | 0.71 |
| Thrombocytopenia (plt <100 G/L) | 32% | 32% | 27% | 0.44 |
| White blood count (WBC), G/L, median (range) | 4.0 (1.0-94) | 4.0 (1.0-18.4) | 4.2 (1.0-18.4) | 0.85 |
| Neutrophil Count (ANC), G/L median (range) | 2.3 (0.2-52.6) | 2.0 (0.2-13.4) | 2.2 (0.3-15.8) | 0.61 |
| Neutropenia (ANC <1.8 G/L) | 36% | 36% | 37% | 0.96 |
| Monocyte count, G/L, median (range) | 0.3 (0-15) | 0.2 (0-0.9) | 0.4 (0-0.9) | 0.0004 |
| Lymphocyte count, G/L, median (range) | 1.2 (0-5.0) | 1.1 (0.1-3.5) | 1.3 (0.3-3.7) | 0.57 |
| Bone marrow | ||||
| % BM blasts, median (range) | 4 (0-14) | 4 (0-13) | 3 (0-19) | 0.086 |
| Dyserythropoiesis | 73% | 75% | 71% | 0.58 |
| Dysgranulopoiesis | 51% | 51% | 69% | 0.025 |
| Dysmegakaryopoiesis | 78% | 80% | 57% | 0.001 |