Table 3.

Multivariable models

VariableCRMRD− OR (95% CI)RFS if CRMRD− HR (95% CI)
WHO AML (ref = MDS EB2) 1.13 (1.05-1.21) 0.8 (0.56-1.15) 
 P <.001 .23 
Age (per 10 y) 0.97 (0.95-0.99) 1.18 (1.08-1.3) 
 P .004 <.001 
PS 2-4 (ref PS 0-1) 0.92 (0.86-0.98) 1.12 (0.82-1.53) 
 P .01 .48 
ELN 2017 intermediate risk (ref favorable risk) 0.82 (0.75-0.88) 2.14 (1.57-2.93) 
 P <.001 <.001 
ELN 2017 adverse risk (ref favorable risk) 0.71 (0.65-0.77) 2.58 (1.8-3.7) 
 P <.001 <.001 
Secondary (ref de novo) 0.88 (0.82-0.94) 0.85 (0.61-1.18) 
 P <.001 .33 
Low-intensity induction (ref high intensity) 0.76 (0.71-0.82) 1.18 (0.81-1.72) 
 P <.001 .39 
Allogeneic HCT (ref no allogeneic HCT) Not applicable 0.27 (0.2-0.38) 
 P  <.001 
VariableCRMRD− OR (95% CI)RFS if CRMRD− HR (95% CI)
WHO AML (ref = MDS EB2) 1.13 (1.05-1.21) 0.8 (0.56-1.15) 
 P <.001 .23 
Age (per 10 y) 0.97 (0.95-0.99) 1.18 (1.08-1.3) 
 P .004 <.001 
PS 2-4 (ref PS 0-1) 0.92 (0.86-0.98) 1.12 (0.82-1.53) 
 P .01 .48 
ELN 2017 intermediate risk (ref favorable risk) 0.82 (0.75-0.88) 2.14 (1.57-2.93) 
 P <.001 <.001 
ELN 2017 adverse risk (ref favorable risk) 0.71 (0.65-0.77) 2.58 (1.8-3.7) 
 P <.001 <.001 
Secondary (ref de novo) 0.88 (0.82-0.94) 0.85 (0.61-1.18) 
 P <.001 .33 
Low-intensity induction (ref high intensity) 0.76 (0.71-0.82) 1.18 (0.81-1.72) 
 P <.001 .39 
Allogeneic HCT (ref no allogeneic HCT) Not applicable 0.27 (0.2-0.38) 
 P  <.001 

Time-dependent Cox regression for RFS; logistic regression for CRMRD−.

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