Table 2.

Non-CVC-associated recurrent thrombotic events

Chronic medical condition (age at recurrence)Initial site of thrombosisRecurrent wite of thrombosisVTE risk factors and anticoagulationTime to recurrent event (d)Patient location of recurrent clot
Congenital heart disease
(17 y) 
Right internal jugular Left internal jugular Sepsis.
Not on anticoagulation. 
380 Pediatric ICU 
Total parenteral nutrition dependence
(16 y) 
Right axillary vein Left portal vein Recent surgery (auto islet cell transplant 2 d prior, occurred via portal vein), immobility.
On full-dose heparin. 
716 Pediatric ICU 
Biliary atresia
(4 mo) 
Right superficial femoral, common femoral, external iliac, and popliteal veins Portal vein Recent surgery (IR liver biopsy 3 d prior), subdural hemorrhage (not associated with anticoagulation).
Not on anticoagulation. 
Inpatient 
Congenital heart disease
(23 mo) 
Left common femoral vein Fontan fenestration Recent surgery (15 d prior lateral tunnel fenestrated Fontan), staph bacteremia, viral gastroenteritis.
Off anticoagulation due to a subdural hemorrhage. 
57 Cardiac ICU 
Congenital heart disease
(12 mo) 
Left brachial vein Left external iliac Respiratory failure, status post congenital twin separation 5 mo prior.
Off anticoagulation due to major bleeding. 
118 Cardiac ICU 
Hypoxic ischemic encephalopathy (8 y) Right common femoral and external iliac veins 
  • 1.

    Right brachial, axillary veins

  • 2.

    Right superficial femoral and popliteal veins

 
Active GI bleeding, heterozygous Factor V Leiden.
Off anticoagulation due to GI bleeding. 
155 Pediatric ICU 
Chronic medical condition (age at recurrence)Initial site of thrombosisRecurrent wite of thrombosisVTE risk factors and anticoagulationTime to recurrent event (d)Patient location of recurrent clot
Congenital heart disease
(17 y) 
Right internal jugular Left internal jugular Sepsis.
Not on anticoagulation. 
380 Pediatric ICU 
Total parenteral nutrition dependence
(16 y) 
Right axillary vein Left portal vein Recent surgery (auto islet cell transplant 2 d prior, occurred via portal vein), immobility.
On full-dose heparin. 
716 Pediatric ICU 
Biliary atresia
(4 mo) 
Right superficial femoral, common femoral, external iliac, and popliteal veins Portal vein Recent surgery (IR liver biopsy 3 d prior), subdural hemorrhage (not associated with anticoagulation).
Not on anticoagulation. 
Inpatient 
Congenital heart disease
(23 mo) 
Left common femoral vein Fontan fenestration Recent surgery (15 d prior lateral tunnel fenestrated Fontan), staph bacteremia, viral gastroenteritis.
Off anticoagulation due to a subdural hemorrhage. 
57 Cardiac ICU 
Congenital heart disease
(12 mo) 
Left brachial vein Left external iliac Respiratory failure, status post congenital twin separation 5 mo prior.
Off anticoagulation due to major bleeding. 
118 Cardiac ICU 
Hypoxic ischemic encephalopathy (8 y) Right common femoral and external iliac veins 
  • 1.

    Right brachial, axillary veins

  • 2.

    Right superficial femoral and popliteal veins

 
Active GI bleeding, heterozygous Factor V Leiden.
Off anticoagulation due to GI bleeding. 
155 Pediatric ICU 

GI, gastrointestinal; ICU, intensive care unit; IR, interventional radiology; VTE, venous thromboembolism.

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