Table 1. Secreted molecules that have an... | American Society of Hematology

Table 1.

Secreted molecules that have an effect on BM MKs

Molecule	Type	Effect	References
CCL5	Cytokine	Positive bias in myeloid cell production	62-64
CXCL12	Cytokine	Regulates the spatial distribution of MKs in the BM	69-70
CXCL4	Cytokine	Negatively promotes HSC proliferation	45, 50, 51
IL-1α	Cytokine	TPO-independent differentiator of MKs	67-68
PAF	Lipid	Affects the growth of human myeloid and erythroid progenitors	81-82
PtdIns3P	Lipid	Involved in DMS formation	79
S1P	Lipid	Involved in MK differentiation and proplatelet formation	85
TGF-β1	Cytokine	Maintains HSC quiescence	47
TNF	Cytokine	Rapid maturation of SL-MkPs and MkPs	5
TPO	Cytokine	Regulates MK differentiation from HSCs	8,10

Molecule	Type	Effect	References
CCL5	Cytokine	Positive bias in myeloid cell production	62-64
CXCL12	Cytokine	Regulates the spatial distribution of MKs in the BM	69-70
CXCL4	Cytokine	Negatively promotes HSC proliferation	45, 50, 51
IL-1α	Cytokine	TPO-independent differentiator of MKs	67-68
PAF	Lipid	Affects the growth of human myeloid and erythroid progenitors	81-82
PtdIns3P	Lipid	Involved in DMS formation	79
S1P	Lipid	Involved in MK differentiation and proplatelet formation	85
TGF-β1	Cytokine	Maintains HSC quiescence	47
TNF	Cytokine	Rapid maturation of SL-MkPs and MkPs	5
TPO	Cytokine	Regulates MK differentiation from HSCs	8,10

DMS, demarcation membrane system; IL-1α, interleukin-1α; PtdIns3P, phosphatidylinositol 3-monophosphate; TNF, tumor necrosis factor.