Cost-effectiveness results for the base case and sensitivity analyses comparing eltrombopag and IVIG
| . | Total cost Mean ± SD . | Treatment success . | Incremental cost (CAD) . | Incremental effect* . |
|---|---|---|---|---|
| Base case | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 8156 ± 4355 | 22 (61.1%) | −413 | 0.18 |
| Sensitivity analyses | ||||
| All medication cost included (ITP and non-ITP) | ||||
| Eltrombopag | 8424 ± 5202 | 30 (78.9%) | ||
| IVIG | 9525 ± 6082 | 22 (61.1%) | −1101 | 0.18 |
| Surgery-related costs excluded† | ||||
| Eltrombopag | 5476 ± 3592 | 30 (78.9%) | ||
| IVIG | 6000 ± 3253 | 22 (61.1%) | −524 | 0.18 |
| Unplanned ER visits and hospitalization costs excluded | ||||
| Eltrombopag | 7597 ± 4804 | 30 (78.9%) | ||
| IVIG | 7752 ± 3898 | 22 (61.1%) | −155 | 0.18 |
| Lowest published cost for eltrombopag (CAD 1.87) | ||||
| Eltrombopag | 6518 ± 4481 | 30 (78.9%) | ||
| IVIG | 8156 ± 4255 | 22 (61.1%) | −1638 | 0.18 |
| Highest published cost for eltrombopag (CAD 7.03) | ||||
| Eltrombopag | 15 178 ± 8154 | 30 (78.9%) | ||
| IVIG | 8156 ± 4255 | 22 (61.1%) | 7022 | 0.18 |
| IVIG 1 g/kg only | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG: 1 g/kg (n = 24) | 7181 ± 4306 | 14 (58.3%) | 562 | 0.21 |
| IVIG 2 g/k only | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG: 2 g/kg (n=12) | 10 457 ± 4897 | 8 (66.6%) | −2714 | 0.12 |
| IVIG per-gram cost varied by −$10 (CAD 40.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 7171 ± 3895 | 22 (61.1%) | 572 | 0.18 |
| IVIG per-gram cost varied by +$10 (CAD 60.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 9142 ± 4624 | 22 (61.1%) | −1399 | 0.18 |
| IVIG per-gram cost varied by −$20 (CAD 30.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 6185 ± 3570 | 22 (61.1%) | 1558 | 0.18 |
| IVIG per-gram cost varied by +20 (CAD 70.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 10 128 ± 5017 | 22 (61.1%) | −2385 | 0.18 |
| Physician visit cost of $51.95 | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 7854 ± 3860 | 22 (61.1%) | −111 | 0.18 |
| . | Total cost Mean ± SD . | Treatment success . | Incremental cost (CAD) . | Incremental effect* . |
|---|---|---|---|---|
| Base case | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 8156 ± 4355 | 22 (61.1%) | −413 | 0.18 |
| Sensitivity analyses | ||||
| All medication cost included (ITP and non-ITP) | ||||
| Eltrombopag | 8424 ± 5202 | 30 (78.9%) | ||
| IVIG | 9525 ± 6082 | 22 (61.1%) | −1101 | 0.18 |
| Surgery-related costs excluded† | ||||
| Eltrombopag | 5476 ± 3592 | 30 (78.9%) | ||
| IVIG | 6000 ± 3253 | 22 (61.1%) | −524 | 0.18 |
| Unplanned ER visits and hospitalization costs excluded | ||||
| Eltrombopag | 7597 ± 4804 | 30 (78.9%) | ||
| IVIG | 7752 ± 3898 | 22 (61.1%) | −155 | 0.18 |
| Lowest published cost for eltrombopag (CAD 1.87) | ||||
| Eltrombopag | 6518 ± 4481 | 30 (78.9%) | ||
| IVIG | 8156 ± 4255 | 22 (61.1%) | −1638 | 0.18 |
| Highest published cost for eltrombopag (CAD 7.03) | ||||
| Eltrombopag | 15 178 ± 8154 | 30 (78.9%) | ||
| IVIG | 8156 ± 4255 | 22 (61.1%) | 7022 | 0.18 |
| IVIG 1 g/kg only | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG: 1 g/kg (n = 24) | 7181 ± 4306 | 14 (58.3%) | 562 | 0.21 |
| IVIG 2 g/k only | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG: 2 g/kg (n=12) | 10 457 ± 4897 | 8 (66.6%) | −2714 | 0.12 |
| IVIG per-gram cost varied by −$10 (CAD 40.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 7171 ± 3895 | 22 (61.1%) | 572 | 0.18 |
| IVIG per-gram cost varied by +$10 (CAD 60.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 9142 ± 4624 | 22 (61.1%) | −1399 | 0.18 |
| IVIG per-gram cost varied by −$20 (CAD 30.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 6185 ± 3570 | 22 (61.1%) | 1558 | 0.18 |
| IVIG per-gram cost varied by +20 (CAD 70.84) | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 10 128 ± 5017 | 22 (61.1%) | −2385 | 0.18 |
| Physician visit cost of $51.95 | ||||
| Eltrombopag | 7743 ± 4897 | 30 (78.9%) | ||
| IVIG | 7854 ± 3860 | 22 (61.1%) | −111 | 0.18 |
All numbers are rounded to the nearest whole number.
CAD, Canadian dollar; ITP, immune thrombocytopenia; IVIG, intravenous immunoglobulin; SD, standard deviation.
Incremental effect is the difference in the rate of achieving platelet count without rescue therapy in eltrombopag and IVIG.
Includes costs associated with transfusion of blood product during surgery and during postoperative hospitalization.