Patients’ baseline characteristics
| Characteristic . | n (%) or median (range) . |
|---|---|
| Age at WM diagnosis, years | 61 (35-91) |
| Age at ibrutinib initiation, years | 68 (40-96) |
| Age >65 years | 190 (60) |
| Male sex | 206 (65) |
| Hemoglobin level, g/dl | 10.3 (4-17) |
| Hemoglobin <11.5 g/dl | 226 (72) |
| Platelet count, K/uL | 211 (9-639) |
| Platelet count <100 K/uL | 42 (13) |
| Serum IgM level, mg/dl | 3400 (88*-10 321) |
| Serum IgM level >4000 mg/dl | 129 (40) |
| Serum IgM level >7000 mg/dl | 15 (5) |
| Serum β2-microglobulin level, mg/l | 3.6 (1.4-18.3) |
| Serum β2-microglobulin level >3 mg/l | 164 (65) |
| Serum albumin level, g/dl | 3.7 (2.1-5) |
| Serum albumin level ≤3.5 g/dl | 92 (30) |
| BM involvement | 60 (5-100) |
| BM involvement ≥60% | 154 (55) |
| IPSSWM | |
| Low | 64 (24) |
| Intermediate | 92 (34) |
| High | 112 (42) |
| MYD88 mutated | 265 (97) |
| CXCR4 mutated | 89 (36) |
| Previously untreated | 100 (31) |
| Previously treated | 219 (69) |
| Median number of prior lines | 2 (1-8) |
| ≥2 prior lines | 115 (53) |
| Characteristic . | n (%) or median (range) . |
|---|---|
| Age at WM diagnosis, years | 61 (35-91) |
| Age at ibrutinib initiation, years | 68 (40-96) |
| Age >65 years | 190 (60) |
| Male sex | 206 (65) |
| Hemoglobin level, g/dl | 10.3 (4-17) |
| Hemoglobin <11.5 g/dl | 226 (72) |
| Platelet count, K/uL | 211 (9-639) |
| Platelet count <100 K/uL | 42 (13) |
| Serum IgM level, mg/dl | 3400 (88*-10 321) |
| Serum IgM level >4000 mg/dl | 129 (40) |
| Serum IgM level >7000 mg/dl | 15 (5) |
| Serum β2-microglobulin level, mg/l | 3.6 (1.4-18.3) |
| Serum β2-microglobulin level >3 mg/l | 164 (65) |
| Serum albumin level, g/dl | 3.7 (2.1-5) |
| Serum albumin level ≤3.5 g/dl | 92 (30) |
| BM involvement | 60 (5-100) |
| BM involvement ≥60% | 154 (55) |
| IPSSWM | |
| Low | 64 (24) |
| Intermediate | 92 (34) |
| High | 112 (42) |
| MYD88 mutated | 265 (97) |
| CXCR4 mutated | 89 (36) |
| Previously untreated | 100 (31) |
| Previously treated | 219 (69) |
| Median number of prior lines | 2 (1-8) |
| ≥2 prior lines | 115 (53) |
Six patients with normal serum IgM levels had an IgM monoclonal spike in the serum protein electrophoresis.