Multivariable models for prognostic analyses
| Prognostic analysis . | HR . | 95% CI . | P . |
|---|---|---|---|
| NRM* | |||
| Age group, y | .13 | ||
| <20 | Ref. | ||
| 20-40 | 1.20 | 0.54-2.67 | |
| 40-60 | 1.07 | 0.39-2.94 | |
| ≥60 | 1.76 | 0.65-4.77 | |
| Sex | .02† | ||
| Female | Ref. | ||
| Male | 0.64 | 0.44-0.92 | |
| Donor type | .007† | ||
| MRD | Ref. | ||
| MUD | 0.98 | 0.62-1.53 | |
| MMD | 2.14 | 1.23-3.72 | |
| rATG exposure groups, AU × day/mL | .01† | ||
| <30 | Ref. | ||
| 30-55 | 1.93 | 0.72-5.17 | |
| ≥55 AU × day/ml | 3.42 | 1.26-9.30 | |
| CMV match | .03† | ||
| R–/D– | Ref. | ||
| R–/D+ | 1.70 | 0.92-3.15 | |
| R+/D– | 1.39 | 0.81-2.38 | |
| R+/D+ | 1.94 | 1.22-3.08 | |
| HCT Comorbidity Index score | <.001† | ||
| 0-1 | Ref. | ||
| 2-3 | 2.16 | 1.40-3.33 | |
| 4-10 | 2.79 | 1.72-4.53 | |
| TBI-based conditioning regimen‡ | .47 | ||
| No | Ref. | ||
| Yes | 0.83 | 0.50-1.38 | |
| NRM in patients with hematologic malignant disorders§ | |||
| Age group, y | .18 | ||
| <20 | Ref. | ||
| 20-40 | 1.17 | 0.48-2.87 | |
| 40-60 | 1.10 | 0.37-3.25 | |
| ≥60 | 1.72 | 0.59-5.02 | |
| Donor type | .002† | ||
| MRD | Ref. | ||
| MUD | 0.90 | 0.57-1.41 | |
| MMD | 2.29 | 1.30-4.02 | |
| rATG exposure groups, AU × day/mL | .007† | ||
| <30 | Ref. | ||
| 30-55 | 7.11 | 0.96-52.6 | |
| ≥55 | 9.88 | 1.31-74.70 | |
| HCT Comorbidity Index score | <.001† | ||
| 0-1 | Ref. | ||
| 2-3 | 2.07 | 1.33-3.21 | |
| 4-10 | 2.43 | 1.49-3.94 | |
| CMV match‡ | .08 | ||
| R–/D– | Ref. | ||
| R–/D+ | 1.68 | 0.91-3.14 | |
| R+/D– | 1.42 | 0.82-2.45 | |
| R+/D+ | 1.84 | 1.14-2.97 | |
| TBI-based conditioning regimen‡ | .58 | ||
| No | Ref. | ||
| Yes | 0.86 | 0.52-1.45 | |
| CD4+IR | |||
| Age groups, y | .19 | ||
| <20 | Ref. | ||
| 20-40 | 0.83 | 0.44-1.57 | |
| 40-60 | 1.98 | 0.67-5.80 | |
| ≥60 | 1.68 | 0.55-5.10 | |
| Donor type | .003† | ||
| MRD | Ref. | ||
| MUD | 0.59 | 0.38-0.91 | |
| MMD | 0.39 | 0.22-0.67 | |
| rATG exposure groups, AU × day/mL | <.001† | ||
| <30 | Ref. | ||
| 30-55 | 0.41 | 0.25-0.66 | |
| ≥55 | 0.35 | 0.17-0.71 | |
| Prognostic analysis . | HR . | 95% CI . | P . |
|---|---|---|---|
| NRM* | |||
| Age group, y | .13 | ||
| <20 | Ref. | ||
| 20-40 | 1.20 | 0.54-2.67 | |
| 40-60 | 1.07 | 0.39-2.94 | |
| ≥60 | 1.76 | 0.65-4.77 | |
| Sex | .02† | ||
| Female | Ref. | ||
| Male | 0.64 | 0.44-0.92 | |
| Donor type | .007† | ||
| MRD | Ref. | ||
| MUD | 0.98 | 0.62-1.53 | |
| MMD | 2.14 | 1.23-3.72 | |
| rATG exposure groups, AU × day/mL | .01† | ||
| <30 | Ref. | ||
| 30-55 | 1.93 | 0.72-5.17 | |
| ≥55 AU × day/ml | 3.42 | 1.26-9.30 | |
| CMV match | .03† | ||
| R–/D– | Ref. | ||
| R–/D+ | 1.70 | 0.92-3.15 | |
| R+/D– | 1.39 | 0.81-2.38 | |
| R+/D+ | 1.94 | 1.22-3.08 | |
| HCT Comorbidity Index score | <.001† | ||
| 0-1 | Ref. | ||
| 2-3 | 2.16 | 1.40-3.33 | |
| 4-10 | 2.79 | 1.72-4.53 | |
| TBI-based conditioning regimen‡ | .47 | ||
| No | Ref. | ||
| Yes | 0.83 | 0.50-1.38 | |
| NRM in patients with hematologic malignant disorders§ | |||
| Age group, y | .18 | ||
| <20 | Ref. | ||
| 20-40 | 1.17 | 0.48-2.87 | |
| 40-60 | 1.10 | 0.37-3.25 | |
| ≥60 | 1.72 | 0.59-5.02 | |
| Donor type | .002† | ||
| MRD | Ref. | ||
| MUD | 0.90 | 0.57-1.41 | |
| MMD | 2.29 | 1.30-4.02 | |
| rATG exposure groups, AU × day/mL | .007† | ||
| <30 | Ref. | ||
| 30-55 | 7.11 | 0.96-52.6 | |
| ≥55 | 9.88 | 1.31-74.70 | |
| HCT Comorbidity Index score | <.001† | ||
| 0-1 | Ref. | ||
| 2-3 | 2.07 | 1.33-3.21 | |
| 4-10 | 2.43 | 1.49-3.94 | |
| CMV match‡ | .08 | ||
| R–/D– | Ref. | ||
| R–/D+ | 1.68 | 0.91-3.14 | |
| R+/D– | 1.42 | 0.82-2.45 | |
| R+/D+ | 1.84 | 1.14-2.97 | |
| TBI-based conditioning regimen‡ | .58 | ||
| No | Ref. | ||
| Yes | 0.86 | 0.52-1.45 | |
| CD4+IR | |||
| Age groups, y | .19 | ||
| <20 | Ref. | ||
| 20-40 | 0.83 | 0.44-1.57 | |
| 40-60 | 1.98 | 0.67-5.80 | |
| ≥60 | 1.68 | 0.55-5.10 | |
| Donor type | .003† | ||
| MRD | Ref. | ||
| MUD | 0.59 | 0.38-0.91 | |
| MMD | 0.39 | 0.22-0.67 | |
| rATG exposure groups, AU × day/mL | <.001† | ||
| <30 | Ref. | ||
| 30-55 | 0.41 | 0.25-0.66 | |
| ≥55 | 0.35 | 0.17-0.71 | |
HR, Hazard Ratio, CI, Confidence Interval, MUD, matched unrelated donor, CMV, cytomegalovirus, TBI, total body irradiation, NRM, Non- Relapse Mortality, CD4+IR, CD4+immune reconstitution, rATG , rabbit antithymocyte globulin
Variables with P < .05 were kept in the final model (with age as an adjustment factor); results of the other variables (at the bottom in italic) are results of the variables added one by one in the final model.
Indicates significance.
Results of the variables are added one by one in the final model.
Multivariable Cox model is adjusted on age; variables with P < .05 are kept in the final model (with age as an adjustment factor); results of the other variables (at the bottom in italic) are results of the variables added one by one in the final model.