Table 3.

Univariable analysis of risk factors for relapse, NRM, OS, and LFS

LFSOSRelapseNRM
HR95% CIPHR95% CIPSub-HR95% CIPSub-HR95% CIP
Baseline covariates 
 Female 0.584 0.229-1.488 .2595 0.730 0.260-2.052 .5504 0.367 0.099-1.359 .1333 1.147 0.290-4.541 .8453 
 Age ≥ 12 y 1.101 0.446-2.720 .8343 1.161 0.420-3.212 .7734 1.064 0.329-3.438 .9173 1.247 0.320-4.865 .7508 
 MMUD (ref: MUD) 1.123 0.450-2.803 .8039 1.281 0.462-3.549 .6345 0.822 0.240-2.823 .7560 1.529 0.399-5.866 .5356 
 ALL (ref: AML) 1.323 0.534-3.281 .5458 1.285 0.463-3.567 .6305 1.091 0.343-3.466 .8827 1.393 0.371-5.235 .6237 
 MRD-positive 1.521 0.434-5.331 .5121 0.460 0.060-3.520 .4545 3.899 1.065-14.271 .0399 * * * 
 CMV status (rec/don) 
  Neg/neg REF REF REF REF REF REF REF REF REF REF REF REF 
  Neg/pos 1.708 0.493-5.912 .3985 1.988 0.443-8.926 .3697 1.743 0.478-6.352 .3999 1.625 0.110-24.007 .7237 
  Pos/neg 0.932 0.270-3.223 .9114 1.170 0.261-5.231 .8376 0.439 0.084-2.297 .3295 2.875 0.298-27.744 .3612 
  Pos/pos 1.157 0.310-4.321 .8283 1.871 0.416-8.425 .4143 0.301 0.033-2.761 .2886 3.951 0.402-38.855 .2388 
 DP match 
 Match REF REF REF REF REF REF REF REF REF REF REF REF 
 Nonpermissive 3.211 0.692-14.889 .1362 6.078 0.759-48.682 .0891 0.806 0.140-4.649 .8097 * * * 
 Permissive 1.013 0.185-5.545 .9884 1.519 0.158-14.618 .7176 0.465 0.065-3.339 .4462 * * * 
 Unknown 1.295 0.237-7.086 .7655 2.107 0.219-20.265 .5189 1.308 0.249-6.864 .7511 0.998 0.646-1.541 .9927 
 ATG-containing (ALL + AML) 1.537 0.621-3.807 .3526 0.846 0.282-2.539 .7657 3.265 0.928-11.489 .0653 0.508 0.121-2.141 .3562 
  AML patients only ∼ ∼ ∼ ∼ ∼ ∼ 5.954 1.100-32.222 .0384 ∼ ∼ ∼ 
 ALL patients only ∼ ∼ ∼ ∼ ∼ ∼ 2.279 0.403-12.877 .3513 ∼ ∼ ∼ 
 Rituximab-containing 0.752 0.249-2.270 .6130 0.855 0.241-3.033 .8085 0.518 0.138-1.948 .3304 1.550 0.189-12.685 .6827 
Time-varying covariates 
 aGVHD, any (ref: none) 2.769 1.120-6.845 .0275 4.229 1.467-12.190 .0076 1.020 0.314-3.317 .9733 7.543 1.617-35.179 .0101 
 aGVHD 
 None REF REF REF REF REF REF REF REF REF REF REF REF 
 Grade 1/2 1.444 0.360-5.787 .6043 1.817 0.445-7.424 .4056 1.238 0.320-4.795 .7572 1.611 0.145-17.891 .6980 
 Grade 3/4 9.364 2.861-30.650 .0002 15.359 4.404-53.559 <.0001 1.587 0.190-13.274 .6697 32.499 4.804-210.871 .0004 
 cGVHD 1.524 0.472-4.919 .4814 2.457 0.700-8.629 .1607 0.431 0.053-3.499 .4309 8.791 1.657-46.650 .0107 
 Adenovirus infection, n = 9 4.049 1.450-11.303 .0076 4.829 1.621-14.383 .0047 1.531 0.331-7.075 .5858 5.258 1.289-21.452 .0207 
 BK virus infection, n = 12 1.383 0.454-4.210 .5683 2.044 0.643-6.494 .2257 0.429 0.059-3.132 .4041 3.854 0.923-16.085 .0642 
 CMV infection, n = 12 1.945 0.699-5.408 .2024 3.5573 0.960-8.374 .0593 0.895 0.202-3.956 .8834 3.155 0.732-13.600 .1232 
 HHV6 infection, n = 6 2.631 0.759-9.114 .1271 3.757 1.046-13.496 .0425 # # # 8.485 2.063-34.901 .0030 
LFSOSRelapseNRM
HR95% CIPHR95% CIPSub-HR95% CIPSub-HR95% CIP
Baseline covariates 
 Female 0.584 0.229-1.488 .2595 0.730 0.260-2.052 .5504 0.367 0.099-1.359 .1333 1.147 0.290-4.541 .8453 
 Age ≥ 12 y 1.101 0.446-2.720 .8343 1.161 0.420-3.212 .7734 1.064 0.329-3.438 .9173 1.247 0.320-4.865 .7508 
 MMUD (ref: MUD) 1.123 0.450-2.803 .8039 1.281 0.462-3.549 .6345 0.822 0.240-2.823 .7560 1.529 0.399-5.866 .5356 
 ALL (ref: AML) 1.323 0.534-3.281 .5458 1.285 0.463-3.567 .6305 1.091 0.343-3.466 .8827 1.393 0.371-5.235 .6237 
 MRD-positive 1.521 0.434-5.331 .5121 0.460 0.060-3.520 .4545 3.899 1.065-14.271 .0399 * * * 
 CMV status (rec/don) 
  Neg/neg REF REF REF REF REF REF REF REF REF REF REF REF 
  Neg/pos 1.708 0.493-5.912 .3985 1.988 0.443-8.926 .3697 1.743 0.478-6.352 .3999 1.625 0.110-24.007 .7237 
  Pos/neg 0.932 0.270-3.223 .9114 1.170 0.261-5.231 .8376 0.439 0.084-2.297 .3295 2.875 0.298-27.744 .3612 
  Pos/pos 1.157 0.310-4.321 .8283 1.871 0.416-8.425 .4143 0.301 0.033-2.761 .2886 3.951 0.402-38.855 .2388 
 DP match 
 Match REF REF REF REF REF REF REF REF REF REF REF REF 
 Nonpermissive 3.211 0.692-14.889 .1362 6.078 0.759-48.682 .0891 0.806 0.140-4.649 .8097 * * * 
 Permissive 1.013 0.185-5.545 .9884 1.519 0.158-14.618 .7176 0.465 0.065-3.339 .4462 * * * 
 Unknown 1.295 0.237-7.086 .7655 2.107 0.219-20.265 .5189 1.308 0.249-6.864 .7511 0.998 0.646-1.541 .9927 
 ATG-containing (ALL + AML) 1.537 0.621-3.807 .3526 0.846 0.282-2.539 .7657 3.265 0.928-11.489 .0653 0.508 0.121-2.141 .3562 
  AML patients only ∼ ∼ ∼ ∼ ∼ ∼ 5.954 1.100-32.222 .0384 ∼ ∼ ∼ 
 ALL patients only ∼ ∼ ∼ ∼ ∼ ∼ 2.279 0.403-12.877 .3513 ∼ ∼ ∼ 
 Rituximab-containing 0.752 0.249-2.270 .6130 0.855 0.241-3.033 .8085 0.518 0.138-1.948 .3304 1.550 0.189-12.685 .6827 
Time-varying covariates 
 aGVHD, any (ref: none) 2.769 1.120-6.845 .0275 4.229 1.467-12.190 .0076 1.020 0.314-3.317 .9733 7.543 1.617-35.179 .0101 
 aGVHD 
 None REF REF REF REF REF REF REF REF REF REF REF REF 
 Grade 1/2 1.444 0.360-5.787 .6043 1.817 0.445-7.424 .4056 1.238 0.320-4.795 .7572 1.611 0.145-17.891 .6980 
 Grade 3/4 9.364 2.861-30.650 .0002 15.359 4.404-53.559 <.0001 1.587 0.190-13.274 .6697 32.499 4.804-210.871 .0004 
 cGVHD 1.524 0.472-4.919 .4814 2.457 0.700-8.629 .1607 0.431 0.053-3.499 .4309 8.791 1.657-46.650 .0107 
 Adenovirus infection, n = 9 4.049 1.450-11.303 .0076 4.829 1.621-14.383 .0047 1.531 0.331-7.075 .5858 5.258 1.289-21.452 .0207 
 BK virus infection, n = 12 1.383 0.454-4.210 .5683 2.044 0.643-6.494 .2257 0.429 0.059-3.132 .4041 3.854 0.923-16.085 .0642 
 CMV infection, n = 12 1.945 0.699-5.408 .2024 3.5573 0.960-8.374 .0593 0.895 0.202-3.956 .8834 3.155 0.732-13.600 .1232 
 HHV6 infection, n = 6 2.631 0.759-9.114 .1271 3.757 1.046-13.496 .0425 # # # 8.485 2.063-34.901 .0030 

Cox models were used for OS and LFS and subdistribution hazard models were used for relapse and NRM.

∼

, Analysis not done.

*

Sample size too small.

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