Distribution of lymphoma histotypes in individuals infected by HIV over 30 years in a European cohort (615 patients) compared with the CNICS USA cohort (476 patients)
| Histotype . | 1986-1995; London (158 patients) . | 1996-2005; London (200 patients) . | 2006-2015; London (257 patients) . | 1996-2000; CNICS (132 patients) . | 2001-2005; CNICS (201 patients) . | 2006-2010; CNICS (143 patients) . |
|---|---|---|---|---|---|---|
| BL | 3% | 10% | 20% ↑ | 7.6% | 10.9% | 16.8% ↑ |
| DLBCL | 63% | 59% | 37% ↓ | 43.9% | 45.8% | 35.7% ↓ |
| HL | 4% | 11% | 26% ↑ | 15.2% | 15.4% | 19.6% ↑ |
| PCNSL | 14.4% | 10.4% | 9.8% ↓ | |||
| PBL | 0 | 2% | 6% ↑ | |||
| PEL | 2% | 1% | 5% ↑ | |||
| Other | 18.9% | 17.4% | 18.2% |
| Histotype . | 1986-1995; London (158 patients) . | 1996-2005; London (200 patients) . | 2006-2015; London (257 patients) . | 1996-2000; CNICS (132 patients) . | 2001-2005; CNICS (201 patients) . | 2006-2010; CNICS (143 patients) . |
|---|---|---|---|---|---|---|
| BL | 3% | 10% | 20% ↑ | 7.6% | 10.9% | 16.8% ↑ |
| DLBCL | 63% | 59% | 37% ↓ | 43.9% | 45.8% | 35.7% ↓ |
| HL | 4% | 11% | 26% ↑ | 15.2% | 15.4% | 19.6% ↑ |
| PCNSL | 14.4% | 10.4% | 9.8% ↓ | |||
| PBL | 0 | 2% | 6% ↑ | |||
| PEL | 2% | 1% | 5% ↑ | |||
| Other | 18.9% | 17.4% | 18.2% |
Since the introduction of cART, the incidence of NHL has decreased by 50% mainly because of decreased PCNSL and the immunoblastic histologic subtype of DLBCL, consistent with CD4 counts. In contrast, the burden of HIV-associated BL and HL has increased16: pre-cART decade (1986-1995); early cART decade (1996-2005); late cART decade (2006-2015). European cohort26; CNICS USA cohort.25 ↑, increase of proportion in late cART decade; ↓, decrease of proportion in late cART decade.