Univariate analysis of 1-y NRM and 1-y OS
| Variable . | 1-y NRM SHR (95% CI) . | 1-y OS HR (95% CI) . |
|---|---|---|
| GA | ||
| Cognitive impairment by BOMC | ||
| <7 | Reference | Reference |
| ≥7 | 2.57 (1.34 to 4.95), P = .005* | 1.56 (0.94 to 2.60), P = .09* |
| IADL | ||
| Normal (14) | Reference | Reference |
| Impaired (<14) | 1.17 (0.69 to 2.06), P = .58 | 1.37 (0.95 to 1.97), P = .09* |
| Physical function by MOS-PH score | ||
| >80 (median score) | Reference | Reference |
| ≤80 | 1.85 (0.94 to 3.61), P = .08* | 1.26 (0.81 to 1.94), P = .30 |
| TUG, s | ||
| <13.5 | Reference | Reference |
| ≥13.5 | 1.38 (0.64 to 2.99), P = .41 | 1.43 (0.86 to 2.38), P = .17 |
| Clinical variables | ||
| Age, y | ||
| 50 to 59 | Reference | Reference |
| 60 to 69 | 1.09 (0.56 to 2.10), P = .80 | 1.27 (0.83 to 1.93), P = .27 |
| ≥70 | 1.66 (0.77 to 3.59), P = .20 | 1.29 (0.75 to 2.22), P = .35 |
| Karnofsky performance status | ||
| 90 to 100 | Reference | Reference |
| <90 | 1.31 (0.72 to 2.41), P = .38 | 1.40 (0.94 to 2.07), P = .1* |
| Comorbidity by HCT-CI | ||
| 0 to 2 | Reference | Reference |
| ≥3 | 2.20 (1.22 to 3.97), P = .009* | 1.28 (0.89 to 1.84), P = .18 |
| DRI | ||
| Low, intermediate | Reference | Reference |
| High, very high | 1.60 (0.87 to 2.93), P = .13 | 1.44 (0.97 to 2.13), P = .07* |
| Conditioning intensity | ||
| Myeloablative conditioning | Reference | Reference |
| Reduced intensity conditioning | 1.48 (0.77 to 2.84), P = .24 | 1.43 (0.95 to 2.15), P = .09* |
| Donor type | ||
| Matched sibling | Reference | Reference |
| Other related | 2.96 (1.02 to 8.59), P = .05 | 1.93 (0.85 to 4.35), P = .11 |
| Well-matched unrelated; 8/8 match | 1.29 (0.63 to 2.68), P = .49 | 1.18 (0.76 to 1.83), P = .46 |
| Partially matched unrelated; 7/8 match | 1.62 (0.57 to 4.63), P = .37 | 1.29 (0.65 to 2.54), P = .47 |
| Cord blood | 2.49 (1.08 to 5.76), P = .03 | 1.80 (1.03 to 3.15), P = .04 |
| Across all donor types, by log rank | P = .14 | P = .22 |
| Graft source | ||
| Bone marrow | Reference | Reference |
| Peripheral blood | 0.68 (0.27 to 1.72), P = .41 | 1.23 (0.60 to 2.53), P = .58 |
| Umbilical cord blood | 1.37 (0.47 to 3.97), P = .57 | 1.88 (0.82 to 4.30), P = .13 |
| Variable . | 1-y NRM SHR (95% CI) . | 1-y OS HR (95% CI) . |
|---|---|---|
| GA | ||
| Cognitive impairment by BOMC | ||
| <7 | Reference | Reference |
| ≥7 | 2.57 (1.34 to 4.95), P = .005* | 1.56 (0.94 to 2.60), P = .09* |
| IADL | ||
| Normal (14) | Reference | Reference |
| Impaired (<14) | 1.17 (0.69 to 2.06), P = .58 | 1.37 (0.95 to 1.97), P = .09* |
| Physical function by MOS-PH score | ||
| >80 (median score) | Reference | Reference |
| ≤80 | 1.85 (0.94 to 3.61), P = .08* | 1.26 (0.81 to 1.94), P = .30 |
| TUG, s | ||
| <13.5 | Reference | Reference |
| ≥13.5 | 1.38 (0.64 to 2.99), P = .41 | 1.43 (0.86 to 2.38), P = .17 |
| Clinical variables | ||
| Age, y | ||
| 50 to 59 | Reference | Reference |
| 60 to 69 | 1.09 (0.56 to 2.10), P = .80 | 1.27 (0.83 to 1.93), P = .27 |
| ≥70 | 1.66 (0.77 to 3.59), P = .20 | 1.29 (0.75 to 2.22), P = .35 |
| Karnofsky performance status | ||
| 90 to 100 | Reference | Reference |
| <90 | 1.31 (0.72 to 2.41), P = .38 | 1.40 (0.94 to 2.07), P = .1* |
| Comorbidity by HCT-CI | ||
| 0 to 2 | Reference | Reference |
| ≥3 | 2.20 (1.22 to 3.97), P = .009* | 1.28 (0.89 to 1.84), P = .18 |
| DRI | ||
| Low, intermediate | Reference | Reference |
| High, very high | 1.60 (0.87 to 2.93), P = .13 | 1.44 (0.97 to 2.13), P = .07* |
| Conditioning intensity | ||
| Myeloablative conditioning | Reference | Reference |
| Reduced intensity conditioning | 1.48 (0.77 to 2.84), P = .24 | 1.43 (0.95 to 2.15), P = .09* |
| Donor type | ||
| Matched sibling | Reference | Reference |
| Other related | 2.96 (1.02 to 8.59), P = .05 | 1.93 (0.85 to 4.35), P = .11 |
| Well-matched unrelated; 8/8 match | 1.29 (0.63 to 2.68), P = .49 | 1.18 (0.76 to 1.83), P = .46 |
| Partially matched unrelated; 7/8 match | 1.62 (0.57 to 4.63), P = .37 | 1.29 (0.65 to 2.54), P = .47 |
| Cord blood | 2.49 (1.08 to 5.76), P = .03 | 1.80 (1.03 to 3.15), P = .04 |
| Across all donor types, by log rank | P = .14 | P = .22 |
| Graft source | ||
| Bone marrow | Reference | Reference |
| Peripheral blood | 0.68 (0.27 to 1.72), P = .41 | 1.23 (0.60 to 2.53), P = .58 |
| Umbilical cord blood | 1.37 (0.47 to 3.97), P = .57 | 1.88 (0.82 to 4.30), P = .13 |
HCT-CI, hematopoietic cell transplant-comorbidity index.
Included in multivariate analysis since P ≤ .1.