Red blood cell %HbF and PGS associations with longitudinal VOP event occurrence in SCCRIP and SAC participants
| . | . | . | SAC . | ||||
|---|---|---|---|---|---|---|---|
| . | . | SCCRIP . | Censored at 11 y . | Censored at 14 y . | |||
| Model description . | Comparison model . | χ2(df) . | P . | χ2(df) . | P . | χ2(df) . | P . |
| Basic model: VOP = sex + age + 5 PCs + HU + −α3.7 | NA | NA | NA | NA | NA | NA | NA |
| %HbF model*: VOP = basic model + %HbF | vs basic model | 8.58 (1) | .0034 | ND | ND | ND | ND |
| HbF SNP model: VOP = basic model + (PGSHbF+ PGSHbF × age) | vs basic model | 9.91 (2) | .007 | 5.5 (2) | .06 | 6.9 (2) | .03 |
| %HbF and HbF SNP model*: VOP = HbF SNP model + %HbF | vs %HbF model vs HbF SNP model | 3.33 (2) 7.94 (1) | .19 .005 | ND | ND | ND | ND |
| COMT model: VOP = basic model + PGSCOMT | vs basic model | 6.68 (1) | .0098 | 2.6 (1) | .11 | 2.6 (1) | .11 |
| HbF SNP and COMT model: VOP = HbF SNP model + PGSCOMT | vs basic model | 16.71 (3) | .0008 | 8.1 (3) | .045 | 9.5 (3) | .02 |
| vs HbF SNP model | 6.80 (1) | .009 | 2.6 (1) | .11 | 2.6 (1) | .11 | |
| vs COMT model | 10.04 (2) | .007 | 5.5 (2) | .06 | 6.9 (2) | .03 | |
| Full model: VOP = HbF SNP and COMT model + PGS5snps + PGS5snps × age | vs HbF SNP model vs HbF SNP and COMT model | 32.45 (3) 25.65 (2) | 4.2 × 10−7 2.7 × 10−6 | ND ND | ND ND | ND ND | ND ND |
| . | . | . | SAC . | ||||
|---|---|---|---|---|---|---|---|
| . | . | SCCRIP . | Censored at 11 y . | Censored at 14 y . | |||
| Model description . | Comparison model . | χ2(df) . | P . | χ2(df) . | P . | χ2(df) . | P . |
| Basic model: VOP = sex + age + 5 PCs + HU + −α3.7 | NA | NA | NA | NA | NA | NA | NA |
| %HbF model*: VOP = basic model + %HbF | vs basic model | 8.58 (1) | .0034 | ND | ND | ND | ND |
| HbF SNP model: VOP = basic model + (PGSHbF+ PGSHbF × age) | vs basic model | 9.91 (2) | .007 | 5.5 (2) | .06 | 6.9 (2) | .03 |
| %HbF and HbF SNP model*: VOP = HbF SNP model + %HbF | vs %HbF model vs HbF SNP model | 3.33 (2) 7.94 (1) | .19 .005 | ND | ND | ND | ND |
| COMT model: VOP = basic model + PGSCOMT | vs basic model | 6.68 (1) | .0098 | 2.6 (1) | .11 | 2.6 (1) | .11 |
| HbF SNP and COMT model: VOP = HbF SNP model + PGSCOMT | vs basic model | 16.71 (3) | .0008 | 8.1 (3) | .045 | 9.5 (3) | .02 |
| vs HbF SNP model | 6.80 (1) | .009 | 2.6 (1) | .11 | 2.6 (1) | .11 | |
| vs COMT model | 10.04 (2) | .007 | 5.5 (2) | .06 | 6.9 (2) | .03 | |
| Full model: VOP = HbF SNP and COMT model + PGS5snps + PGS5snps × age | vs HbF SNP model vs HbF SNP and COMT model | 32.45 (3) 25.65 (2) | 4.2 × 10−7 2.7 × 10−6 | ND ND | ND ND | ND ND | ND ND |
The PGSs are defined in Table 3. χ2 values were calculated by subtracting the deviance of the larger model with more independent variables from that of the smaller model and were used to calculate P values. The −α3.7 status was not available for the SAC cohort. df, degree of freedom; ND, not determined. NA, not applicable.
A total of 1095 longitudinal RBC %HbF values were available for 284 of 327 SCCRIP participants analyzed for VOP event occurrence. These %HbF data were used in the %HbF model and the %HbF + HbF SNP model.