Definitions of treatment failure events in current treatment protocols
| Event . | Methods . | Study group . |
|---|---|---|
| Induction failure (EOI) ≥5% blasts in BM | Cytomorphology and/or FCM-/PCR-MRD or genetics | JCCG, SEHOP-PETHEMA, SFCE, SJCRH, TPOG |
| Induction failure (EOI) ≥25% blasts in BM | See above | DFCI, UKALL |
| No induction failure events; treatment failure is an event if CR has not been achieved at later timepoints | Different combinations of methods | AIEOP-BFM, ALLTogether, ALL-IC-BFM, CoALL, COG, DCOG, EsPhALL-COG, NOPHO |
| Event . | Methods . | Study group . |
|---|---|---|
| Induction failure (EOI) ≥5% blasts in BM | Cytomorphology and/or FCM-/PCR-MRD or genetics | JCCG, SEHOP-PETHEMA, SFCE, SJCRH, TPOG |
| Induction failure (EOI) ≥25% blasts in BM | See above | DFCI, UKALL |
| No induction failure events; treatment failure is an event if CR has not been achieved at later timepoints | Different combinations of methods | AIEOP-BFM, ALLTogether, ALL-IC-BFM, CoALL, COG, DCOG, EsPhALL-COG, NOPHO |
BM: bone marrow, EOI: end of induction, FCM-MRD: flow cytometric minimal residual disease, MRD: minimal residual disease, PCR-MRD: polymerase chain reaction minimal residual disease.