Table 3. Consensus criteria for relapse... | American Society of Hematology

Table 3.

Consensus criteria for relapse definition in pediatric ALL: BM relapse (MRD available)

BM 1		BM 2^*
MRD	Others	MRD
≥25%	Not necessary to define relapse	Not necessary to define relapse
Five to <25%	One other test^‡ with ≥1% blasts	Not necessary to define relapse
Five to <25%	None	Two tests^† with with ≥1% blasts
One to <5%	Two other tests^† with with ≥1% blasts	Not necessary to define relapse
One to <5%	Zero or 1 other test^‡ with ≥1% blasts	Two tests^† with ≥1% blasts

BM 1		BM 2^*
MRD	Others	MRD
≥25%	Not necessary to define relapse	Not necessary to define relapse
Five to <25%	One other test^‡ with ≥1% blasts	Not necessary to define relapse
Five to <25%	None	Two tests^† with with ≥1% blasts
One to <5%	Two other tests^† with with ≥1% blasts	Not necessary to define relapse
One to <5%	Zero or 1 other test^‡ with ≥1% blasts	Two tests^† with ≥1% blasts

Second bone marrow evaluation ≥1 wk later.

FCM/PCR/NGS-based MRD or FISH/karyotype/PCR demonstrating leukemia-specific marker or M2/M3 morphology.