Risk factors associated with decreased OS
| . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|
| Variables . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Subtype | ||||||
| CDX2-high | 2.86 | 1.29-6.33 | .0097 | 3.48 | 1.54-7.86 | .0026 |
| IDH1/2-mut | 4.68 | 1.67-13.09 | .0033 | 4.86 | 1.70-13.91 | .0032 |
| Ph-like | 2.99 | 1.80-4.97 | 2.3 × 10−5 | 2.04 | 1.16-3.59 | .014 |
| Age ≥40 | 2.07 | 1.33-3.23 | .0013 | 2.13 | 1.34-3.38 | .0013 |
| Male sex | 1.29 | 0.83-2.01 | .27 | 1.41 | 0.88-2.26 | .15 |
| WBC ≥30 000 | 1.86 | 1.18-2.92 | .0074 | 1.81 | 1.07-3.06 | .028 |
| . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|
| Variables . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Subtype | ||||||
| CDX2-high | 2.86 | 1.29-6.33 | .0097 | 3.48 | 1.54-7.86 | .0026 |
| IDH1/2-mut | 4.68 | 1.67-13.09 | .0033 | 4.86 | 1.70-13.91 | .0032 |
| Ph-like | 2.99 | 1.80-4.97 | 2.3 × 10−5 | 2.04 | 1.16-3.59 | .014 |
| Age ≥40 | 2.07 | 1.33-3.23 | .0013 | 2.13 | 1.34-3.38 | .0013 |
| Male sex | 1.29 | 0.83-2.01 | .27 | 1.41 | 0.88-2.26 | .15 |
| WBC ≥30 000 | 1.86 | 1.18-2.92 | .0074 | 1.81 | 1.07-3.06 | .028 |
References for categorial variables were as follows: cases not assigned to indicated subtypes, aged 39 years or younger, female sex, and WBC of less than 30 000. Patients undergoing stem cell transplantation were not censored at the time of transplantation. CI, confidence interval; HR, hazards ratio; WBC, white blood cells.