Table 3. Malignancy modifies effect of... | American Society of Hematology

Table 3.

Malignancy modifies effect of obesity on M and ISI

	M			ISI*
	β^†	95% CI	P	β^†	95% CI	P
Univariable model 1
Malignancy	1.9	−0.2 to 4.1	.078	31.0	13.4-48.6	.001
Intercept	7.2	5.8-8.7	<.001	28.6	16.8-40.4	<.001
Univariable model 2
BMI	−0.2	−0.3 to −0.1	<.001	−2.0	−2.8 to −1.1	<.001
Intercept	15.2	11.5-18.9	<.001	113.6	82.7-144.4	<.001
Multivariable model
Malignancy	10.1	0.7-19.4	.036	104.0	26.7-181.2	.010
BMI	−0.10	−0.30 to 0.02	.093	−0.9	−2.1 to 0.3	.152
Male sex	−1.9	−4.2 to 0.3)	.085	−8.3	−25.6 to 10	.365
Non-White race	0.004	−2.3 to 2.3	.997	0.6	−18.4 to 19.6	.950
Malignancy × BMI interaction	−0.3	−0.6 to −0.01	.042	−2.6	−4.8 to −0.4	.024
Intercept	12.8	7.1-18.6	<.001	66.1	18.9-113.4	.007

	M			ISI*
	β^†	95% CI	P	β^†	95% CI	P
Univariable model 1
Malignancy	1.9	−0.2 to 4.1	.078	31.0	13.4-48.6	.001
Intercept	7.2	5.8-8.7	<.001	28.6	16.8-40.4	<.001
Univariable model 2
BMI	−0.2	−0.3 to −0.1	<.001	−2.0	−2.8 to −1.1	<.001
Intercept	15.2	11.5-18.9	<.001	113.6	82.7-144.4	<.001
Multivariable model
Malignancy	10.1	0.7-19.4	.036	104.0	26.7-181.2	.010
BMI	−0.10	−0.30 to 0.02	.093	−0.9	−2.1 to 0.3	.152
Male sex	−1.9	−4.2 to 0.3)	.085	−8.3	−25.6 to 10	.365
Non-White race	0.004	−2.3 to 2.3	.997	0.6	−18.4 to 19.6	.950
Malignancy × BMI interaction	−0.3	−0.6 to −0.01	.042	−2.6	−4.8 to −0.4	.024
Intercept	12.8	7.1-18.6	<.001	66.1	18.9-113.4	.007

ISI = M/I.

Negative β values indicate increasing insulin resistance associated with the variable of interest.