Toxicity rates according to optimal and suboptimal fludarabine exposure
| Characteristic . | Suboptimal (<13.8 mg × h/L) . | Optimal (≥13.8 mg × h/L) . | P . |
|---|---|---|---|
| CRS grade ≥3 (severe CRS) | 15/50 (30) | 18/102 (18) | .09 |
| ICANS grade ≥1 | 9/31 (29) | 15/67 (22) | .61 |
| ICANS grade ≥3 (severe ICANS) | 4/31 (13) | 5/67 (7) | .46 |
| Characteristic . | Suboptimal (<13.8 mg × h/L) . | Optimal (≥13.8 mg × h/L) . | P . |
|---|---|---|---|
| CRS grade ≥3 (severe CRS) | 15/50 (30) | 18/102 (18) | .09 |
| ICANS grade ≥1 | 9/31 (29) | 15/67 (22) | .61 |
| ICANS grade ≥3 (severe ICANS) | 4/31 (13) | 5/67 (7) | .46 |
Data presented as n/N (%).